Results 1 to 10 of about 1,506,940 (201)

Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels

open access: yesESC Heart Failure, 2023
Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers ...
Arnold Péter Ráduly   +9 more
doaj   +1 more source

Heart Transplantation as a Treatment Method for Refractory Heart Failure due to Post-myocarditis Dilated Cardiomyopathy: a Clinical Case

open access: yesВопросы современной педиатрии, 2019
Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such
Larisa A. Balykova   +7 more
doaj   +1 more source

Hemodynamic Profile of the Cardiotonic Agent Pimobendan

open access: yesJournal of Cardiovascular Pharmacology, 1989
Pimobendan (UD-CG 115 BS) is a potent positive inotropic agent with vasodilatory properties. This hemodynamic profile was demonstrated in conscious rabbits chronically instrumented with Doppler flow probes. Pimobendan (10, 30, 100, and 300 micrograms/kg i.v.) increased cardiac output, stroke volume, heart rate, and mesenteric, renal, and hindquarter ...
J C, van Meel, W, Diederen
openaire   +3 more sources

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

open access: yesFrontiers in Pharmacology, 2020
A new coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) has emerged and with it, a global investigation of new antiviral treatments and supportive care for organ failure due to this life-threatening viral infection.
Roodabeh Bahramsoltani   +3 more
doaj   +1 more source

Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure

open access: yes针刺研究, 2011
Digitalis glycosides,a group of cardiotonic agents for heart failure,have been used for a long time,but may often trigger arrhythmias as a result of digitalis intoxication.It is of great significance in finding a method to reduce their toxicity and ...
MA Shu-hua1   +8 more
doaj   +2 more sources

Efeitos agudos de levosimendana e dobutamina na duração do QRS em Pacientes com insuficiência cardíaca Efectos agudos de levosimendana y dobutamina en la duración del QRS en pacientes con insuficiencia cardíaca Acute effects of levosimendan and dobutamine on QRS duration in patients with heart failure

open access: yesArquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: A levosimendana é um novo agente inotrópico que aumenta a contratilidade cardíaca sem aumentar a captação celular de cálcio, de forma a não causar sobrecarga de cálcio e arritmias relacionadas.
Osman Can Yontar   +4 more
doaj  

Pandanus odoratissimus (Kewda): A Review on Ethnopharmacology, Phytochemistry, and Nutritional Aspects

open access: yesAdvances in Pharmacological Sciences, 2014
Pandanus odoratissimus Linn. (family: Pandanaceae) is traditionally recommended by the Indian Ayurvedic medicines for treatment of headache, rheumatism, spasm, cold/flu, epilepsy, wounds, boils, scabies, leucoderma, ulcers, colic, hepatitis, smallpox ...
Prafulla P. Adkar, V. H. Bhaskar
doaj   +1 more source

Studies on cardiotonic agents. VII. Potent cardiotonic agent KF15232 with myofibrillar Ca2+ sensitizing effect.

open access: yesChemical and Pharmaceutical Bulletin, 1991
A series of novel 4,5-dihydro-5-methyl-6-(2 or 4-substituted 7-quinazolinyl)-3(2H)-pyridazinones was synthesized and examined for cardiotonic activity in anesthetized dogs. The 4-substituted aminoquinazolines generally showed potent and long-lasting inotropic activity.
NOMOTO, Yuji   +3 more
openaire   +3 more sources

Identification of Bioactive Agents and Immunomodulatory Factors from Seashells of the Persian Gulf

open access: yesIranian South Medical Journal, 2010
Background: Research in marine pharmacology will promise new bioactive agents. The marine bioenvironment is the unique resource for bioactive agents that could not be found in terrestrial organisms.
Arezoo Najafi   +3 more
doaj  

The Significance of the Cardiac Peptide NT-proBNP in the Assessment of Risk for Myocardial Revascularization in Patients with Decreased Left Ventricular Ejection Fraction

open access: yesОбщая реаниматология, 2010
Objective: to substantiate a procedure for predicting the severity of postperfusion acute heart failure (AHF) from the baseline level of NT-proBNP during myocardial revascularization in patients with a left ventricular ejection fraction (LVEF) of less ...
V. V. Moroz   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy