Results 1 to 10 of about 8,494 (210)

Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress [PDF]

Clinics, 2009
OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated
Adriano Meneghini, Celso Ferreira, Luiz Carlos de Abreu, Vitor E. Valenti, Marcelo Ferreira, Celso F. Filho, Neif Murad   +6 more
doaj   +7 more sources

Effects of statins on serum sCD40, sCD146 and PAPP-An in patients with coronary heart disease [PDF]

Journal of Medical Biochemistry
Background: To analyse the effects of statins on the levels of sCD40, sCD146 and PAPP-An in patients with coronary heart disease (CHD). Methods: 126 patients with CHD treated from September 2022 to September 2024 were divided into a study group (n = 84 ...
Li Huawen, Zhou Xia, Zhu Wenyan, Zhang Jing   +3 more
doaj   +2 more sources

Acute poisoning by cardiovascular agents [PDF]

Vojnosanitetski Pregled, 2003
In order to determine the frequency, severity of poisoning, and the efficacy of the applied therapeutic measures, retrospective study of 391 patients treated for acute drug poisoning was performed during one-year period at the Clinic for Emergency and ...
Vučinić Slavica, Vučinić Žarko, Šegrt Zoran, Joksović Dragan, Jovanović Dušan, Todorović Veljko   +5 more
doaj   +1 more source

Steroids—has the time come to extend their use to AML?

Journal of the Egyptian National Cancer Institute, 2021
Background In 2018, leukaemia accounted for 2.6% of all new cancers, it being the 13th most common cause of cancer and the 10th most common cause of cancer death. Glucocorticoids are commonly used in lymphoid leukaemia treatment, where they are cytotoxic.
Mariah Farrugia, Catriona Cutajar, Jean Calleja Agius, Pierre Schembri Wismayer   +3 more
doaj   +1 more source

Cardiac Glycosides as Immune System Modulators

Biomolecules, 2021
Cardiac glycosides (CGs) are natural steroid compounds occurring both in plants and animals. They are known for long as cardiotonic agents commonly used for various cardiac diseases due to inhibition of Na+/K+-ATPase (NKA) pumping activity and modulating
Jan Škubník, Vladimíra Pavlíčková, Silvie Rimpelová   +2 more
doaj   +1 more source

Antiviral activity of ouabain against a Brazilian Zika virus strain

Scientific Reports, 2022
Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena   +9 more
doaj   +1 more source

Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics

Biomolecules, 2021
Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well recognized and accepted in the treatment of various cardiac diseases as they can increase the rate ...
Ranjith Kumavath, Sayan Paul, Honey Pavithran, Manash K. Paul, Preetam Ghosh, Debmalya Barh, Vasco Azevedo   +6 more
doaj   +1 more source

Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19

Viruses, 2021
Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity against a South Korean Middle ...
Meehyun Ko, So Young Chang, Soo Young Byun, Aleksandr Ianevski, Inhee Choi, Anne-Laure Pham Hung d’Alexandry d’Orengiani, Erlend Ravlo, Wei Wang, Magnar Bjørås, Denis E. Kainov, David Shum, Ji-Young Min, Marc P. Windisch   +12 more
doaj   +1 more source

Clinical Characteristics and Treatment of Atrial Fibrillation and Heart Failure: a Multicenter Survey [PDF]

Zhongguo quanke yixue, 2023
Background Atrial fibrillation (AF) is a common clinical tachyarrhythmia with high prevalence, and a predisposing factor of stroke. In addition, it has a causal relationship with heart failure (HF) .
HU Huachao, CHEN Xianya, XIE Siyuan, XIA Zhen, XIAO Hua
doaj   +1 more source

The hypotensive effect of salt substitutes in stage 2 hypertension:a systematic review and meta-analysis [PDF]

, 2020
Background: Hypertension (HTN) is a ubiquitous risk factor for numerous non-communicable diseases, including cardiovascular disease and stroke. There are currently no wholly effective pharmacological therapies for subjects with HTN.
Clark, Cain C T, Ebrahimzadeh, Armin, Jafarnejad, Sadegh, Mirzaei, Hamed, Taghizadeh, Mohsen   +4 more
core   +2 more sources