Results 1 to 10 of about 6,043 (171)
Seminars in Anesthesia, Perioperative Medicine and Pain, 1996 D RUGS THAT INCREASE the positive inotropic (ie, cardiotonic) potential of the myocardium are used in a variety of clinical settings. All catecholamines exert their inotropic effects by stimulating adrenergic mediated receptors in the sympathetic nervous system.
Roberta Hines, Stephen Harris
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Hemodynamic Profile of the Cardiotonic Agent Pimobendan
Journal of Cardiovascular Pharmacology, 1989 Pimobendan (UD-CG 115 BS) is a potent positive inotropic agent with vasodilatory properties. This hemodynamic profile was demonstrated in conscious rabbits chronically instrumented with Doppler flow probes. Pimobendan (10, 30, 100, and 300 micrograms/kg i.v.) increased cardiac output, stroke volume, heart rate, and mesenteric, renal, and hindquarter ...
J C, van Meel, W, Diederen
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A Quantum Chemical Conformational Study of some Novel Cardiotonic Agents
, 1993 Department of Chemistry, Lady Keane College, Shillong·793 001 Manuscript received 28 January 1992 revised 25 September 1992, accepted 29 October 1992 Ethyl 5-cyano-1,6-dihydro-6-oxo-3-pyridine carboxylates are recently reported compounds which exhibit ...
APURBA KRISHNA BHATTACHARJEE
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Assessing cardiotonic steroids involvement in hypertensive rat models with Helicobacter pylori infections [PDF]
, 2020 Dissertation (MSc)--University of Pretoria 2020.Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality.
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, 2003 A new class of cardiotonic agents characterized by a 2-pyridone structure was synthesized. Appropriate sym-2-dimethylaminomethylene-1,3-diones reacted with methylcyanoacetate to afford the desired compounds.
FOSSA, PAOLA +4 more
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Cardiotonic steroids on the road to anti-cancer therapy.
, 2007 The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the ...
Mijatovic, Tatjana +5 more
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Hemodynamic effects of calcium-sensitizing agents
, 1995 Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced ...
Papp Gyula +3 more
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Oxygen-Saving Effect of a New Cardiotonic Agent, MCI-154, in Diseased Human Hearts1
, 1997 Objectives. The aim of this study was to examine the left ventricular mechanoenergetic effects of a novel Ca2+sensitizing agent, MCI-154, on diseased human hearts compared with dobutamine.Background.
Katsuya Hata +13 more
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Cardiotonic Steroids-Mediated Targeting of the Na+/K+-ATPase to Combat Chemoresistant Cancers.
, 2012 A large proportion of cancer patients fail to respond to conventional chemotherapy because of the intrinsic resistance of their cancer to pro-apoptotic stimuli and/or the acquisition of a multidrug resistant (MDR) phenotype during chronic chemotherapy. A
Mijatovic, Tatjana +2 more
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LR: 20031114; PUBM: Print; JID: 0372554; 0 (Anti-Arrhythmia Agents); 0 (Cardiotonic Agents); 0 (Cardiovascular Agents); ppublishSource type: Electronic ...
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