Results 11 to 20 of about 6,043 (171)
Quantitative structure - activity relationships of cardiotonic agents
, 2000 Quantitative structure-activity relationships (QSARs) of different cardiotonic agents are presented. A critical analysis of all QSARs provides a very vivid picture of the mechanisms of varying cardiotonic agents. The cardiotonics can be broadly put into 2 categories: cardiac glycosides and nonglycoside cardiotonics, which include phosphodiesterase of ...
Satya P Gupta
exaly +4 more sources
Cardiovascular Toxicology, 2005 We sought to determine the relative myotoxicity of a sample of cardiotonic (catecholaminergic and PDE Inhibitory) agents currently available for clinical use.
Jatin G Burniston +2 more
exaly +2 more sources
Mechanisms of Action of Novel Cardiotonic Agents
Journal of Cardiovascular Pharmacology, 2002 Regulation of myocardial contractility by cardiotonic agents is achieved by an increase in intracellular Ca2+ mobilization (upstream mechanism), an increase in Ca2+ binding affinity to troponin C (central mechanism), or facilitation of the process subsequent to Ca2+ binding to troponin C (downstream mechanism).
Masao Endoh
openaire +3 more sources
Chemical and Pharmaceutical Bulletin, 1991 A series of novel 4,5-dihydro-5-methyl-6-(2 or 4-substituted 7-quinazolinyl)-3(2H)-pyridazinones was synthesized and examined for cardiotonic activity in anesthetized dogs. The 4-substituted aminoquinazolines generally showed potent and long-lasting inotropic activity.
NOMOTO, Yuji +3 more
openaire +4 more sources
, 1984 Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
openaire +2 more sources
Calcium Signaling and Pharmacology of Cardiotonic Agents
, 1995 The mechanisms of action of drugs that act on myocardial contractility through different signal transduction pathways have lately been elucidated to a great extent, in particular since the introduction of novel methods for detecting changes in the intracellular concentration of Ca++ ions, ([Ca++] i), by the application of aequorin, quin-2, fura-2 and ...
Masao Endoh
openaire +2 more sources
Procedural Characteristics and Safety of Slender Percutaneous Coronary Intervention: Slender Is Better. [PDF]
Catheter Cardiovasc IntervABSTRACT Objectives We aimed to examine the procedural characteristics and safety profile of slender percutaneous coronary interventions (PCI) using a 5 Fr or smaller sheath. Background Smaller catheter size has been associated with fewer complications in PCI.
Yoshimachi F +11 more
europepmc +2 more sources
Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]
ChemistryWe describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N +3 more
europepmc +2 more sources