Procedural Characteristics and Safety of Slender Percutaneous Coronary Intervention: Slender Is Better. [PDF]
Catheter Cardiovasc IntervABSTRACT Objectives We aimed to examine the procedural characteristics and safety profile of slender percutaneous coronary interventions (PCI) using a 5 Fr or smaller sheath. Background Smaller catheter size has been associated with fewer complications in PCI.
Yoshimachi F +11 more
europepmc +2 more sources
Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]
ChemistryWe describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N +3 more
europepmc +2 more sources
Frontiers in Pharmacology, 2023 Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered.
Ji-Chao Zhou +20 more
doaj +1 more source
Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies
Pharmaceutics, 2023 Biodetoxification using intravenous lipid emulsion (ILE) in acute poisoning is of growing interest. As well as for local anesthetics, ILE is currently used to reverse toxicity caused by a broad-spectrum of lipophilic drugs.
Karim Jaffal +2 more
doaj +1 more source
Therapeutic Effect of Echium amoenum on Isoproterenol-Induced Heart Failure in Male Rat [PDF]
Research Journal of PharmacognosyBackground and objectives: Echium amoenum has shown anti-inflammatory and antioxidants properties and is suggested for heart disease in Persian medicine. Methods: To evaluate its cardioprotective effects, 50 male Wistar rats were divided into five groups:
Hossein Jafari +6 more
doaj +1 more source
Micropropagation for the production of high quality phytochemicals [PDF]
, 2013 Plants area source of many valuable secondary metabolites that find a broad field of applications, ranging from the agrochemical to the pharmaceutical industries.
Grevenstuk, Tomás, Romano, Anabela
core +1 more source
Precision medicine considerations for the management of heart disease and stroke in East Asians
Cardiology Plus, 2020 Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by ...
Candida L Goodnough, Eric R Gross
doaj +1 more source
Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study [PDF]
, 2013 ObjectiveAcidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. This study evaluated the effects of colforsin, which directly activates adenylate
Hagiya Keiichi +7 more
core +1 more source
Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect
Azar Hosseini +3 more
doaj +1 more source
Biology, 2020 Melanoma is the most common cancer in young adults, with a constantly increasing incidence. Metastatic melanoma is a very aggressive cancer with a 5-year survival rate of about 22−25%.
Laura Soumoy +8 more
doaj +1 more source