Results 11 to 20 of about 1,506,940 (201)
Use of intravenous lipid emulsions in drug-induced toxicities: a 2025 narrative review [PDF]
Annals of Intensive CareIntravenous lipid emulsions (ILE) were first proposed in 1998 as a treatment for bupivacaine-induced cardiac arrest. Since then, their use has expanded to include poisonings by various lipophilic drugs such as tricyclic antidepressants, calcium channel ...
Gauthier Nendumba +4 more
doaj +2 more sources
Effects of statins on serum sCD40, sCD146 and PAPP-An in patients with coronary heart disease [PDF]
Journal of Medical BiochemistryBackground: To analyse the effects of statins on the levels of sCD40, sCD146 and PAPP-An in patients with coronary heart disease (CHD). Methods: 126 patients with CHD treated from September 2022 to September 2024 were divided into a study group (n = 84 ...
Li Huawen +3 more
doaj +2 more sources
3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities [PDF]
Journal of Advanced Biomedical and Pharmaceutical Sciences, 2021 Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as natural products and formed the integral backbone of great number of drugs in the market.
Gamal El-Din Abuo-Rahma +5 more
doaj +1 more source
Discovery of Ro 41-0960, a Non-Steroidal Inhibitor of the Na<sup>+</sup>/K<sup>+</sup>-ATPase. [PDF]
ChemMedChemRo 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Cruz-Cortés C +5 more
europepmc +2 more sources
Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B [PDF]
, 2021 This article describes a concise synthesis of cardiotonic steroids oleandrigenin (7) and its subsequent elaboration into the natural product rhodexin B (2) from the readily available intermediate (8) that could be derived from the ...
Pavel, Nagorny +2 more
core +2 more sources
Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease. [PDF]
J Clin MedInflammatory bowel disease (IBD) is a chronic condition that significantly impairs the quality of life of millions of individuals. The pathogenesis of IBD is closely linked to dysbiosis of microbiota and the activation of various inflammatory pathways ...
Cavalcante-Silva LHA +5 more
europepmc +2 more sources
Acute poisoning by cardiovascular agents [PDF]
Vojnosanitetski Pregled, 2003 In order to determine the frequency, severity of poisoning, and the efficacy of the applied therapeutic measures, retrospective study of 391 patients treated for acute drug poisoning was performed during one-year period at the Clinic for Emergency and ...
Vučinić Slavica +5 more
doaj +1 more source
Steroids—has the time come to extend their use to AML?
Journal of the Egyptian National Cancer Institute, 2021 Background In 2018, leukaemia accounted for 2.6% of all new cancers, it being the 13th most common cause of cancer and the 10th most common cause of cancer death. Glucocorticoids are commonly used in lymphoid leukaemia treatment, where they are cytotoxic.
Mariah Farrugia +3 more
doaj +1 more source
Antiviral activity of ouabain against a Brazilian Zika virus strain
Scientific Reports, 2022 Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho +9 more
doaj +1 more source
Cardiac Glycosides as Immune System Modulators
Biomolecules, 2021 Cardiac glycosides (CGs) are natural steroid compounds occurring both in plants and animals. They are known for long as cardiotonic agents commonly used for various cardiac diseases due to inhibition of Na+/K+-ATPase (NKA) pumping activity and modulating
Jan Škubník +2 more
doaj +1 more source