Results 31 to 40 of about 6,043 (171)

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

Exploring the Anticancer, Anti‐Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora: Insights into the Phytochemical Composition

ChemistryOpen, Volume 14, Issue 11, November 2025.
Stachys longiflora extract was prepared by ultrasonic extraction method. The phytochemicals in the extracts were analyzed by liquid chromatography‐electrospray tandem mass spectrometry. The antibiofilm activity against Staphylococcus aureus ATCC 25923 was assessed using the MTT method and scanning electron microscopy.
Ecem GÜLDAR, Sevim Feyza ERDOĞMUŞ, Cengiz SARIKURKCU   +2 more
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Food Frontiers, Volume 6, Issue 5, Page 2108-2128, September 2025.
This review systematically and comprehensively analyzes hawthorn (Crataegus spp.), covering its bioactive constituents, properties, and processed products. ABSTRACT Hawthorn is widely cultivated in China, with excellent varieties and steadily increasing production.
Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu, Ningyang Li   +7 more
wiley   +1 more source

Na+/K+-ATPase as a target for cardiotonic steroids and cisplatin [PDF]

, 2017
The sodium (Na+)/potassium (K+)-ATPase is an ion pump located on the surface of all animal cells. It pumps three sodium ions out of the cell while pumping two potassium ions into the cell, hydrolyzing one ATP molecule as the driving force for the ...
Suzuki, Kuniaki, Deyama, Yoshiaki, Yoshimura, Yoshitaka, Minamikawa, Hajime   +3 more
core  

The association between red blood cell transfusion timing and the development of retinopathy of prematurity: Application of the two‐phase theory

Acta Ophthalmologica, Volume 103, Issue 6, Page 645-651, September 2025.
Abstract Purpose Red blood cell (RBC) transfusions are believed to be associated with retinopathy of prematurity (ROP), but the underlying mechanism is not fully understood, partly due to the lack of information on RBC transfusion timing. The aim was to determine the association between the timing and amount of RBC transfusions and the development and ...
Salma El Emrani, Lizanne A. Derks, Angela M. Tjiam, Michaela van Bohemen, Jacqueline U. M. Termote, Lotte E. van der Meeren, Irwin K. M. Reiss, H. Rob Taal, Enrico Lopriore, Nicoline E. Schalij‐Delfos   +9 more
wiley   +1 more source

Cardiotonic Steroids Suppress Adenovirus Replication

, 2018
Human adenoviruses are common pathogens that can cause life-threatening illness, yet no approved therapies are available for treatment. This work shows that two cardiotonic steroids, digoxin and digitoxin, inhibit adenovirus replication in A549 lung ...
Grosso, Filomena Sarina
core  

<b>A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1<i>H</i>)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents</b>

, 2010
A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium ...
Majid M. Heravi, Maliheh Khorshidi, Bita Baghernejad, Khorshidi, Maliheh, Yahia Sh. Beheshtia, Baghernejad, Bita, Sh. Beheshtia, Yahia, M. Heravi, Majid   +7 more
core   +1 more source

Trajectories of Physical Activity During a 6‐Month Mobile App‐Based Lifestyle Modification Intervention in Physically Inactive Adults With Cardiovascular Risk Factors

Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 8, August 2025.
ABSTRACT Mobile app‐based health promotion allows frequent and longitudinal monitoring of lifestyle modifications for cardiovascular prevention. We explored the trajectories of physical activity (PA) during mobile app‐based disease management programs in adults with cardiovascular risk using group‐based trajectory modeling (GBTM). Male participants who
Takuji Adachi, Takahiro Miki, Kotoe Shimizu, Masashi Kanai, Yuta Hagiwara   +4 more
wiley   +1 more source

Cardiac effects of r-79595 and its isomers (r-80122 and r-80123) in an acute heart-failure model - a new class of cardiotonic agents with highly selective phosphodiesterase-iii inhibitory properties

, 1992
R 79595 (N-cyclohexyl-N-methyl-2-[[[phenyl (1,2,3,5-tetrahydro-2 oxoimidazo [2,1-b]-quinazolin-7-yl) methylene] amin] oxy] acetamide) and its isomers represent a novel class of compounds with phosphodiesterase (PDE) inhibitory and cardiotonic (positive ...
CONRAD, C, DECOURCELLES, DD, SCHNEIDER, J, Peters, Thies, BECK, E, WILFFERT, B, HEERS, C   +6 more
core   +1 more source