Results 31 to 40 of about 1,506,940 (201)
Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament
Journal of Pharmacological Sciences, 2009 Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation ...
Naoto Tadano +5 more
doaj +1 more source
Biology, 2020 Melanoma is the most common cancer in young adults, with a constantly increasing incidence. Metastatic melanoma is a very aggressive cancer with a 5-year survival rate of about 22−25%.
Laura Soumoy +8 more
doaj +1 more source
Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect
Azar Hosseini +3 more
doaj +1 more source
Frontiers in Physiology, 2020 Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina +5 more
doaj +1 more source
Cardiotonic Steroids Suppress Adenovirus Replication [PDF]
, 2018 Human adenoviruses are common pathogens that can cause life-threatening illness, yet no approved therapies are available for treatment. This work shows that two cardiotonic steroids, digoxin and digitoxin, inhibit adenovirus replication in A549 lung ...
Grosso, Filomena Sarina
core +1 more source
Ontology acquisition and exchange of evolutionary product-brokering agents [PDF]
, 2004 Agent-based electronic commerce (e-commerce) has been booming with the development of the Internet and agent technologies. However, little effort has been devoted to exploring the learning and evolving capabilities of software agents.
Guan, SU, Zhu, F
core +6 more sources
A Quantum Chemical Conformational Study of some Novel Cardiotonic Agents
, 1993 Department of Chemistry, Lady Keane College, Shillong·793 001 Manuscript received 28 January 1992 revised 25 September 1992, accepted 29 October 1992 Ethyl 5-cyano-1,6-dihydro-6-oxo-3-pyridine carboxylates are recently reported compounds which exhibit ...
APURBA KRISHNA BHATTACHARJEE
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Oxygen-Saving Effect of a New Cardiotonic Agent, MCI-154, in Diseased Human Hearts1 [PDF]
, 1997 Objectives. The aim of this study was to examine the left ventricular mechanoenergetic effects of a novel Ca2+sensitizing agent, MCI-154, on diseased human hearts compared with dobutamine.Background.
Katsuya Hata +13 more
core +1 more source
Assessing cardiotonic steroids involvement in hypertensive rat models with Helicobacter pylori infections [PDF]
, 2020 Dissertation (MSc)--University of Pretoria 2020.Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality.
core +1 more source
JSFA reports, EarlyView.Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed +5 more
wiley +1 more source