Results 51 to 60 of about 1,506,940 (201)
DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling
Aging Cell, Volume 25, Issue 9, September 2026.In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li +11 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.Rosa damascena flowers, buds, leaves, branches, and hydrodistillation by‐products were investigated using FTIR‐ATR, LC–MS/MS, and a series of biological assays. The integrated approach highlighted the chemical diversity and bioactive potential of both plant materials and industrial processing residues, supporting their sustainable valorization ...
Burak Bayrak +11 more
wiley +1 more source
Cardiotonic steroids on the road to anti-cancer therapy.
, 2007 The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the ...
Mijatovic, Tatjana +5 more
core +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.Crataegus monogyna fruit extract attenuated oxidative stress and inflammatory responses in acetic acid‐induced ulcerative colitis in rats. Treatment improved antioxidant status, reduced lipid peroxidation, and alleviated histopathological damage, demonstrating its protective effect against ulcerative colitis.
Soumaya Wahabi +4 more
wiley +1 more source
Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa
Feddes Repertorium, Volume 137, Issue 2, June 2026.ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan +2 more
wiley +1 more source
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
PHARMACOLOGICAL MECHANISM OF ACTION OF CARDIOTONIC AGENTS
The article examines the pharmacological mechanism of action of cardiotonic agents aimed at increasing the contractile function of the myocardium and improving hemodynamics.
Турумбаева, Айзада
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Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu +11 more
wiley +1 more source
Hemodynamic effects of calcium-sensitizing agents
, 1995 Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced ...
Papp Gyula +3 more
core +1 more source
Formal Verification of Neural Agents in Non-deterministic Environments [PDF]
, 2020 We introduce a model for agent-environment systems where the agents are implemented via feed-forward ReLU neural networks and the environment is non-deterministic. We study the verification problem of such systems against CTL properties.
Akintunde, Michael E. +4 more
core +1 more source