Results 51 to 60 of about 6,043 (171)

Abstracts

open access: yesMolecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Inotropic drugs and their mechanisms of action

open access: yes, 1984
This report describes various old and new positive inotropic drugs with respect to their mechanisms of action. Drugs with established cardiotonic effects include cardiac glycosides, beta,-adrenergic agents, glucagon, histamine and the methylxanthines ...
Scholz, Hasso, Hasso Scholz
core   +1 more source

Ataxia, Areflexia, Ophthalmoplegia

open access: yes, 1979
Blurred vision; Diplopia; Bilateral papilledemaA 40-year old male with a 3-week history of progressively worsening, blurred and double vision.Limited horizontal movements OU; Abducting nystagmus ODElevated CSF proteinIV ACTH; Corticosteroids; Vasodilator
Nancy M. Newman, MD; J. Selhorst, MD
core  

Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament

open access: yes, 2009
Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation ...
Toshiyuki Sasaguri   +5 more
core   +1 more source

Actions of amrinone and milrinone on the guinea-pig ileum

open access: yes, 1988
The pharmacological activity of the cardiotonic agents amrinone and milrinone has been examined on the isolated guinea-pig ileum. Both compounds antagonised the presynaptic inhibitory action of adenosine on electrically evoked contractions, milrinone ...
D M Paton, T W Stone
core   +1 more source

Circulatory shock: definition, classification, diagnosis and treatment

open access: yes, 2003
Procede sucinta revisão, procurando abordar, de forma sistematizada e prática, a classificação, diagnóstico e tratamento do choque circulatório. São essencialmente enfatizados aspectos conceituais, além de achados clínicos, hemodinâmicos e metabólicos ...
Schmidt, André, Siqueira, Bruno Ganem
core   +1 more source

The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells.

open access: yes, 2009
We recently reported that over-expressed Na(+)/K(+)-ATPase alpha subunits are new important anti-cancer targets. Cardiotonic steroids are the natural ligands of Na(+)/K(+)-ATPase and thus potentially potent anti-cancer agents with a novel mechanism of ...
Hoda, Mir Ali Reza   +6 more
core   +1 more source

Considerations on the utility of Digitalis lanata species for drug industry [PDF]

open access: yes, 2008
Digitalis lanata has a well-deserved place in drug industry.This interest dates back in 1785, when the effects of Digitalis lanata extracts were discovered and digoxin became part of the heart failure treatment.
Vătavu, Roxana   +2 more
core   +1 more source

Inotropic Agents. Synthesis and Structure-Activity Relationships of New Milrinone Related cAMP PDEIII inhibitors

open access: yes, 1997
The synthesis of 6-substituted 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles 1b,c, 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarbonitriles 1d-g and esters of 5-cyano-1,6-dihydro-2-methyl-6-oxo-3-pyridinecarboxylic acid 2b-e is described.
BOGGIA, RAFFAELLA   +5 more
core  

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