Results 41 to 50 of about 5,916 (165)

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments

Кубанский научный медицинский вестник, 2015
On the model of systemic inflammatory response syndrome caused by toxi-allergic myocarditis 10-day duration in rabbits the efficacy of 5 days (beginning after 5 days from the injection of staphylococcus toxins) administration of the various ...
D. I. Ionov, M. M. Fedorova, G. V. Sukoyan, P. A. Galenko-Yaroshevsky, N. V. Gongadze   +4 more
doaj  

Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation

Neurogastroenterology &Motility, Volume 37, Issue 12, December 2025.
Impact of Wild Edible Fruits of Arbutus unedo and Crataegus monogyna on Gut Motility, Contraction, Secretion, and Glucose Regulation. ABSTRACT Background Arbutus and hawthorn fruits are commonly utilized in traditional medicine to address various gastrointestinal (GI) ailments.
Soumaya Wahabi, Kais Rtibi, Chaima Abidi, Mourad Jridi, Bernard Gressier, Hichem Sebai, Bruno Eto   +6 more
wiley   +1 more source

Considerations about Study on Mechanisms of Acupuncture Underlying Efficacy-enhancement and Toxicity-attenuation of Digitalis Drugs for Heart Failure

针刺研究, 2011
Digitalis glycosides,a group of cardiotonic agents for heart failure,have been used for a long time,but may often trigger arrhythmias as a result of digitalis intoxication.It is of great significance in finding a method to reduce their toxicity and ...
MA Shu-hua1, GAO Jun-hong2, WANG Yu-min1, ZHANG Meng3, MA Yan-yan1, HU Jian-jiang1, FU Wei-xing2, CUI Hai-feng1, YU Xiao-chun1   +8 more
doaj  

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

Exploring the Anticancer, Anti‐Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora: Insights into the Phytochemical Composition

ChemistryOpen, Volume 14, Issue 11, November 2025.
Stachys longiflora extract was prepared by ultrasonic extraction method. The phytochemicals in the extracts were analyzed by liquid chromatography‐electrospray tandem mass spectrometry. The antibiofilm activity against Staphylococcus aureus ATCC 25923 was assessed using the MTT method and scanning electron microscopy.
Ecem GÜLDAR, Sevim Feyza ERDOĞMUŞ, Cengiz SARIKURKCU   +2 more
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

Bassia indica Attenuates Cardiotoxicity in a Rat Model via Anti-Inflammatory, Antioxidant, and Keap1/Nrf2 Modulation

Pharmaceuticals
Background: Drug-induced cardiotoxicity is a primary concern in clinical practice, especially in the context of oxidative stress induced by anti-cancer, antiviral, and antidiabetic drugs.
Fayyaz Anjum, Saad Touqeer, QurratUlAin Jamil, Ayesha Rida, Hafiz Muhammad Zubair, Adeel Sarfraz, Saleh Alfuraih, Waad Alrohily, Ali F. Almutairy, Ashfaq Ahmad, Mohammed Aufy, Shahid Muhammad Iqbal   +11 more
doaj   +1 more source

THE NEUROPROTECTIVE EFFECTS OF HAWTHORN-BASED MEDICATIONS

Паёми Сино
The purpose of this review is to summarize and organize the existing literature data on the antidepressant activity of drugs derived from plants in the genus Crataegus L.
Kurkin Vladimir Aleksandrovich, Kudashkina Nataliya Vladimirovna, Zaripov Nurali Abdurakibovich, Pravdivtseva Olga Evgenievna, Zaytseva Elena Nikolaevna, Khasanova Svetlana Rashitovna   +5 more
doaj   +1 more source