Results 21 to 30 of about 5,916 (165)

Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

Frontiers in Physiology, 2020
Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina, Artem Mikhaylovich Tverskoi, Artem Mikhaylovich Tverskoi, Elizaveta Andreevna Klimanova, Svetlana Vadimovna Sidorenko, Sergei Nikolaevich Orlov   +5 more
doaj   +1 more source

Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels

ESC Heart Failure, 2023
Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers ...
Arnold Péter Ráduly, Attila Tóth, Fruzsina Sárkány, Balázs Horváth, Norbert Szentandrássy, Péter P. Nánási, Zoltán Csanádi, István Édes, Zoltán Papp, Attila Borbély   +9 more
doaj   +1 more source

Heart Transplantation as a Treatment Method for Refractory Heart Failure due to Post-myocarditis Dilated Cardiomyopathy: a Clinical Case

Вопросы современной педиатрии, 2019
Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such
Larisa A. Balykova, Elena I. Naumenko, Nataljya V. Ivyanskaya, Yulia A. Petrushkina, Ekaterina A. Vlasova, Nadezhda N. Urzjaeva, Irina V. Leontieva, Anna N. Urzjaeva   +7 more
doaj   +1 more source

Bioinspired Synthesis of Twin abeo‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M. Zimmerman, Pavel Nagorny   +7 more
wiley   +2 more sources

An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2

Frontiers in Pharmacology, 2020
A new coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) has emerged and with it, a global investigation of new antiviral treatments and supportive care for organ failure due to this life-threatening viral infection.
Roodabeh Bahramsoltani, Roodabeh Bahramsoltani, Roja Rahimi, Roja Rahimi   +3 more
doaj   +1 more source

Hemodynamic Profile of the Cardiotonic Agent Pimobendan

Journal of Cardiovascular Pharmacology, 1989
Pimobendan (UD-CG 115 BS) is a potent positive inotropic agent with vasodilatory properties. This hemodynamic profile was demonstrated in conscious rabbits chronically instrumented with Doppler flow probes. Pimobendan (10, 30, 100, and 300 micrograms/kg i.v.) increased cardiac output, stroke volume, heart rate, and mesenteric, renal, and hindquarter ...
J C, van Meel, W, Diederen
openaire   +3 more sources

Comprehensive Chemical and Biological Evaluation of Rosa damascena Plant Parts and Industrial Residues Using FTIR‐ATR and LC–MS/MS

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Rosa damascena flowers, buds, leaves, branches, and hydrodistillation by‐products were investigated using FTIR‐ATR, LC–MS/MS, and a series of biological assays. The integrated approach highlighted the chemical diversity and bioactive potential of both plant materials and industrial processing residues, supporting their sustainable valorization ...
Burak Bayrak, Hafize Yuca, Yasemin Beyza Budak, Satuk Buğra Alkuyruk, Elif Beyza Özer, Gülnur Ekşi Bona, Bilge Aydın, Mehmet Karadayı, Yusuf Gülşahin, Alptuğ Atila, Gamze Göger, Songul Karakaya   +11 more
wiley   +1 more source

Preventive Effects of Crataegus monogyna Fruit Extract on Oxidative Damage and Inflammatory Response in a Rat Model of Acetic Acid‐Induced Ulcerative Colitis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Crataegus monogyna fruit extract attenuated oxidative stress and inflammatory responses in acetic acid‐induced ulcerative colitis in rats. Treatment improved antioxidant status, reduced lipid peroxidation, and alleviated histopathological damage, demonstrating its protective effect against ulcerative colitis.
Soumaya Wahabi, Dhekra Grami, Khaoula Gharbi, Slimen Selmi, Hichem Sebai   +4 more
wiley   +1 more source

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source