Results 21 to 30 of about 8,494 (210)
Seminars in Anesthesia, Perioperative Medicine and Pain, 1996 D RUGS THAT INCREASE the positive inotropic (ie, cardiotonic) potential of the myocardium are used in a variety of clinical settings. All catecholamines exert their inotropic effects by stimulating adrenergic mediated receptors in the sympathetic nervous system.
Roberta Hines, Stephen Harris
openaire +1 more source
Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament
Journal of Pharmacological Sciences, 2009 Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation ...
Naoto Tadano +5 more
doaj +1 more source
Frontiers in Physiology, 2020 Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina +5 more
doaj +1 more source
"Oxygen sensing" by Na,K-ATPase: These miraculous thiols [PDF]
, 2016 Control over the Na,K-ATPase function plays a central role in adaptation of the organisms to hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its "oxygen-sensitivity" is mediated by a variety of redox-sensitive ...
Bogdanova, Anna +2 more
core +2 more sources
ESC Heart Failure, 2023 Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers ...
Arnold Péter Ráduly +9 more
doaj +1 more source
Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District. [PDF]
, 2012 BACKGROUND\ud \ud The Kagera region of north western Tanzania has a rich culture of traditional medicine use and practice. Traditional medicines are the mainstay of healthcare in this region and are known to support the management of many illnesses such ...
Moshi, Mainen J +2 more
core +2 more sources
Ion pumps as biological targets for decavanadate [PDF]
, 2013 The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a ...
Aureliano, M.
core +1 more source
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma +7 more
wiley +2 more sources
A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells [PDF]
, 2013 Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the leaves of this ...
Burgos Morón, Estefanía +4 more
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Вопросы современной педиатрии, 2019 Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such
Larisa A. Balykova +7 more
doaj +1 more source