Results 81 to 90 of about 19,509 (183)

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2028-2048, July 2026.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 193-202, July 2026.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

Long‐Term Follow‐Up of Patients With Mitochondrial Carbonic Anhydrase VA Deficiency. A Case Report and Literature Review

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Mitochondrial carbonic anhydrase VA (CA‐VA) deficiency is a rare inherited metabolic disorder caused by biallelic variants of the CA5A gene. It presents with hyperammonemia, lactic acidosis, and ketonuria, with or without hypoglycemia. We report the long‐term follow‐up of the first two reported cases of CA‐VA deficiency: a 16‐year‐old female ...
Shaymaa Shurrab, Amira Mobarak, Gabriella Horvath, Sylvia Stocker‐Ipsiroglu, Clara van Karnebeek, Ramona Salvarinova‐Zivkovic   +5 more
wiley   +1 more source

Butane Toxicity: Severe Multi‐Organ Dysfunction in an Adolescent Following Butane Inhalation: A Case Report

Journal of Paediatrics and Child Health, EarlyView.
Hannah R. Reichel, Rahul S. Joshi
wiley   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, Volume 36, Issue 7, Page 767-777, July 2026.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE‐MAKE): A Protocol for a Pre‐Planned Sub‐Study of a Randomized Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Acute kidney injury (AKI) is a common and serious complication after cardiac arrest, affecting more than 30% of initially successfully resuscitated patients, with around 10% receiving Kidney Replacement Therapy (KRT). Currently, treatment options to prevent renal complications are limited.
Keski‐Keturi M, Niemelä V.H, Young P, Nielsen N, Wise M.P, Reinikainen M, Bass F, Lilja G, Dankiewicz J, Hammond N, Hästbacka J, Levin H, Moseby‐Knappe M, Saxena M, Tiainen M, Ceric A, Kamp C.B, Sillassen C.D.B, Alexandersson D, Schmidbauer S, Tirkkonen J, Oksanen T, Säkkinen H, Bendel S, Düring J, Lybeck A, Johnsson J, Unden J, Lundin A, Kåhlin J, Grip J, Lotman E, Romundstad L, Seidel P, Stammet P, Graf T, Mengel A, Leithner C, Nee J, Druwé P, Ameloot K, McGuigan P.J, White J, Govier M, Ostermann M, Hopkins P, Proudfoot A, Handslip R, Pogson D, Jackson P, Nichol A, Haenggi M, Hilty M.P, Iten M, Schrag C, Nafi M, Joannidis M, Robba C, Belohlavek J, Rob D, Arabi Y, Al‐Fares A, Yew Woon C, Aneman A, Stewart A, Arnott C, Ramanan M, Panwar R, Delaney A, Reade M, Venkatesh B, Taccone F, Pekkarinen P.T, Friberg H, Cronberg T, Jakobsen J.C, Skrifvars M.B   +76 more
wiley   +1 more source

Septic shock: treatment and modern interpretation of the issue

Український журнал клінічної хірургії
Objective. To analyse the results of treatment of patients with septic shock, which was carried out in accordance with the decisions of the International Conference on Conciliation and the protocols of the Sepsis–3 guideline. Materials and methods. We
С. D. Shapoval
doaj   +1 more source

Electrocardiographic Correlates of Myocardial Remodeling After Cardiac Resynchronization Therapy

Pacing and Clinical Electrophysiology, EarlyView.
Christian Toquica, Amulya Gupta, Tucker Morey, Christopher J. Harvey, Seth H. Sheldon, Madhu Reddy, Amit Noheria   +6 more
wiley   +1 more source

Remifentanil Versus Rocuronium for Optimising Video Laryngoscopy Assisted Tracheal Intubation—The ROCVIDEO Trial Protocol

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Routine use of neuromuscular blocking agents (NMBAs) is widely recommended to facilitate tracheal intubation. However, NMBA use is associated with potential adverse effects, including postoperative respiratory complications, intraoperative awareness and anaphylaxis.
Emil Ørskov Ipsen, Lars Hyldborg Lundstrøm, Åse Lodenius, Gustav Fisker, Magnus Fuhr Hovind, Christian Lindgren Nielsen, Hrund Oskarsdottir, Camilla Strøm, Charlotte Vallentin Rosenstock, Karl Peter Damgård Madsen, Sine Wichmann, Arash Afshari, Jacob Hessel Andersen, Helene Korvenius Nedergaard, Louise Bill, Maria Cronhjort, Ole Mathiesen, Janus Christian Jakobsen, Matias Vested, Anders Kehlet Nørskov   +19 more
wiley   +1 more source

Surgical Outcomes in the Era of COVID-19: A Stratified Analysis Based on Infection Chronology

Український журнал серцево-судинної хірургії
Aim. To investigate the impact of COVID-19 infection timing on postoperative outcomes in patients undergoing surgical treatment for acquired valvular heart disease. Materials and Methods.
Dmytro M. Kosovan
doaj   +1 more source