Results 61 to 70 of about 1,013,334 (248)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
PyIO: Input-Output Analysis with Python [PDF]
This is a User Manual about PyIO, an Input-Output analysis tool using Python. Up to date software is available from the Regional Economics Applications Laboratory (University of Illinois at Urbana-Champaign) homepage. http://www.uiuc.edu/unit/real/
Suahasil Nazara +3 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Tourism and Economic Development in Romania: Input-Output Analysis Perspective [PDF]
Tourism provides a lot of opportunities for sustainable economic development. At local level, by its triggering effect it could represent a factor of economic recovery, by putting to good use the local material and human potential.
GHEORGHE ZAMAN +3 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Revista de Métodos Cuantitativos para la Economía y la Empresa, 2018 Esta investigación se inicia con las siguientes interrogantes: ¿existe consistencia entre la identificación de desarrollo y la estructura económica que se posee?; ¿existen parecidos entre economías identificadas con distintos niveles de desarrollo?; y ...
Soza-Amigo, Sergio, Aroca, Patricio
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interregional Interdependence among Ecuadorian Provinces: An Input-Output Analysis [PDF]
In this paper, we explore the structural characteristics of the interregional input-output system developed for Ecuador for the year 2007. As part of an ongoing project that aims to develop an interregional CGE model for the country, this database was ...
Eduardo Haddad +4 more
core
The emission benefits of European integration
Environmental Research Letters, 2019 Simulating the implications of Brexit on the UK’s emissions embodied in trade with a multi-region input–output table exposes the benefits of European integration. Under 2014 trade volumes, technologies and energy mixes, a hard Brexit—reverting to a trade
Luís Costa, Vincent Moreau
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source