Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Simple input-output dependencies explain neuronal activity. [PDF]
Nat PhysLynn CW.
europepmc +1 more source
EXOGENIZING AGRICULTURE IN AN INPUT-OUTPUT MODEL TO ESTIMATE RELATIVE IMPACTS OF DIFFERENT FARM TYPES [PDF]
In this study, aggregate, provincial level impact for various farm types are estimated for Saskatchewan based on an input-output table constructed for the province.
Johnson, Thomas G. +1 more
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Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Nanoscale protein clustering modulates the input-output response of cellular signalling pathways. [PDF]
Sci RepPanconi L, Griffié J, Owen DM.
europepmc +1 more source
Interdependence Among the Brazilian States: An Input-Output Approach [PDF]
The principal aim of this paper is to evaluate the interregional linkages based on the many-region input-output table for Brazilian regions, for the year 1996, elaborated by FIPE.
Eduardo Haddad +2 more
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A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Automated Classification of Homeostasis Structure in Input-Output Networks. [PDF]
Bull Math BiolLin X, Antoneli F, Wang Y.
europepmc +1 more source
Atmospheric Pollution and Consumption Patterns in Spain: An Input-Output Approach [PDF]
This paper analyses the relationship between Spanish household consumption patterns and atmospheric pollutant emissions in 2000. Applying an input-output approach we estimate the relative responsibility of different types of households in the emissions ...
Mònica Serrano, Jordi Roca
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source