Results 31 to 40 of about 1,001,525 (341)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Input-Output Approach to Regional Employment [PDF]

Statistika: Statistics and Economy Journal, 2017
The paper deals with statistical data on regional employment that was constructed on the basis of regional input-output tables. Both regional input-output tables and product linked regional employment were constructed within the research project.
Jaroslav Sixta
doaj  

Correlation entropy of synaptic input-output dynamics

, 2006
The responses of synapses in the neocortex show highly stochastic and nonlinear behavior. The microscopic dynamics underlying this behavior, and its computational consequences during natural patterns of synaptic input, are not explained by conventional ...
A. Harsch, B. Sakmann, C. Webber, Jr., D. Cox, G. Fuhrmann, Hugh P. C. Robinson, Ingo C. Kleppe, J. A. Varela, J. S. Dittman, L. Cao, L. F. Abbott, R. C. Malenka   +11 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Learning Moore Machines from Input-Output Traces

, 2016
The problem of learning automata from example traces (but no equivalence or membership queries) is fundamental in automata learning theory and practice.
A Gupta, A Solar-Lezama, AV Aleksandrov, AW Biermann, B Jonsson, C Higuera de la, CL Heitmeyer, D Angluin, D Lee, EM Gold, EM Gold, F Aarts, F Aarts, F Howar, HI Akram, IP Buzhinsky, J Oncina, K Meinke, K Takahashi, KJ Lang, LPJ Veelenturf, M Shahbaz, M Spichakova, MA Colón, MJ Heule, O Grinchtein, P Dupont, R Alur, R Dorofeeva, S Cassel, T Berg, TM Mitchell, TS Chow, V Ulyantsev, X Jin, Z Kohavi   +35 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Export Potential Assessment Methodology: The Case of the Republic of Uzbekistan [PDF]

Финансовый журнал
This paper proposes a universal methodology for assessing export potential of different countries. It takes into account both external and internal supply and demand factors.
Sergei S. Sudakov, Alexey A. Zinchenko
doaj   +1 more source

The Dichotomy Between 'Input Legitimacy' and "Output Legitimacy" in the Light of the EU Institutional Developments

European Papers, 2020
(Series Information) European Papers - A Journal on Law and Integration, 2020 5(1), 225-236 | Article | (Table of Contents) I. The dichotomy's original purposes. - II. The distinction between redistributive and regulatory policies. - III.
Cesare Pinelli
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source