Results 61 to 70 of about 4,019,444 (298)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Regional Input Output Table for the State of Punjab [PDF]
Because of policy relevance of regional input-output analysis, a vast literature on the construction of regional input-output tables has emerged in the recent past, especially on the non-survey and hybrid methods. Although, construction of regional input-
Singh, Inderjeet, Singh, Lakhwinder
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
THE MAGIC TRIANGLE OF INPUT-OUTPUT TABLES
World Review of Political Economy, 2010 Input-output tables (I-O tables) can play an important role in delivering a suitable data base for studies on sustainable development.
Carsten Stahmer
doaj +1 more source
OUTPUT CHANGE IN U.S. AGRICULTURE: AN INPUT-OUTPUT ANALYSIS [PDF]
This paper analyzes output changes in the U.S. agricultural economy from 1972 to 1977 using a 477-sector input-output framework. The empirical model is based on benchmark input-output data from the U.S.
Holland, David W., Martin, R.P.
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Interregional Flows for the Czech Economy [PDF]
Statistika: Statistics and Economy Journal, 2018 The paper brings both the methodology and data on the construction of regional flows in the interregional model. We focus on the comparison of the entropy method and the commonly used gravity method.
Karel Šafr, Jaroslav Sixta
doaj
"Input-output Structure and Growth in China" [PDF]
The fast and steady economic growth in China during the 1990s has attracted much international attention. Using the three most recent Chinese input-output tables, this paper investigates industry structure and inter-industry relationships and the ...
Michael McAleer, Baiding Hu
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Illustration of Single-Regional and Inter-Regional Approach in Regional Input-Output Analysis [PDF]
Statistika: Statistics and Economy Journal, 2017 Analytical works usually use single-regional approach which does not demand so much data. However, this approach disregards flows of output among regions.
Karel Šafr, Ktristýna Vltavská
doaj