Results 31 to 40 of about 802,718 (224)

Data-Driven Linear Representations of Forced Nonlinear MIMO Systems via Hankel Dynamic Mode Decomposition with Lifting

Mathematics
Modeling forced nonlinear multivariable dynamical systems remains challenging, particularly when first-principles models are unavailable or strong nonlinear couplings are present.
Marcos Villarreal-Esquivel, Juan Francisco Durán-Siguenza, Luis Ismael Minchala   +2 more
doaj   +1 more source

Episodic Learning with Control Lyapunov Functions for Uncertain Robotic Systems [PDF]

, 2019
Many modern nonlinear control methods aim to endow systems with guaranteed properties, such as stability or safety, and have been successfully applied to the domain of robotics.
Ames, Aaron D., Dorobantu, Victor D., Le, Hoang M., Taylor, Andrew J., Yue, Yisong   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Data-driven modelling of biological multi-scale processes

, 2015
Biological processes involve a variety of spatial and temporal scales. A holistic understanding of many biological processes therefore requires multi-scale models which capture the relevant properties on all these scales.
Hasenauer, Jan, Hross, Sabrina, Jagiella, Nick, Theis, Fabian J.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Algebraic approach to synthesis of data-driven control design for dissipativity

SICE Journal of Control, Measurement, and System Integration
Model-based control methods play an important role in control theory. Such controllers are designed via system identification; however, this approach is not applicable to cases where it is difficult to execute system identification owing to the large ...
Yuki Tanaka, Osamu Kaneko, Takeyuki Sueyoshi   +2 more
doaj   +1 more source

Mechanisms for the generation and regulation of sequential behaviour [PDF]

, 2003
A critical aspect of much human behaviour is the generation and regulation of sequential activities. Such behaviour is seen in both naturalistic settings such as routine action and language production and laboratory tasks such as serial recall and many ...
Cooper, Richard P.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Solving the Synthesis Problem Self-Organizing Control System in the Class of Elliptical Accidents Optics for Objects with One Input and One Output

Computation
Nonlinear single-input single-output (SISO) systems operating under parametric uncertainty often exhibit bifurcations, multistability, and deterministic chaos, which significantly limit the effectiveness of classical linear, adaptive, and switching ...
Maxot Rakhmetov, Ainagul Adiyeva, Balaussa Orazbayeva, Shynar Yelezhanova, Raigul Tuleuova, Raushan Moldasheva   +5 more
doaj   +1 more source