Results 31 to 40 of about 52,175 (253)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Reservoir computing with output feedback

, 2011
Reinhart RF. Reservoir computing with output feedback. Bielefeld: Bielefeld University; 2011.A dynamical system approach to forward and inverse modeling is proposed. Forward and inverse models are trained in associative recurrent neural networks that are
Reinhart, René Felix, Reinhart, Felix
core   +1 more source

Algebraic approach to synthesis of data-driven control design for dissipativity

SICE Journal of Control, Measurement, and System Integration
Model-based control methods play an important role in control theory. Such controllers are designed via system identification; however, this approach is not applicable to cases where it is difficult to execute system identification owing to the large ...
Yuki Tanaka, Osamu Kaneko, Takeyuki Sueyoshi   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

An intrinsic behavioural approach to the gap metric [PDF]

, 2008
An intrinsic trajectory level approach without any recourse to an algebraic structure of a representation is utilized to develop a behavioural approach to robust stability.
Bian, Wenming, BIAN, WM, PILLAI, HK, Pillai, Harish, French, Mark, FRENCH, M   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Benchmarking Carbon Emissions Performance in Supply Chains [PDF]

, 2014
Purpose – The paper aims to develop a benchmarking framework to address issues such as supply chain complexity and visibility, geographical differences and non-standardized data, ensuring that the entire supply chain environmental impact (in terms of ...
Genovese, A, Genovese, Andrea, Acquaye, Adolf, Barrett, J., Barrett, John W., Acquaye, A., Genovese, A., Koh, S.C.L., Barrett, J, Koh, SCL, Koh, Lenny, Acquaye, A   +11 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Solving the Synthesis Problem Self-Organizing Control System in the Class of Elliptical Accidents Optics for Objects with One Input and One Output

Computation
Nonlinear single-input single-output (SISO) systems operating under parametric uncertainty often exhibit bifurcations, multistability, and deterministic chaos, which significantly limit the effectiveness of classical linear, adaptive, and switching ...
Maxot Rakhmetov, Ainagul Adiyeva, Balaussa Orazbayeva, Shynar Yelezhanova, Raigul Tuleuova, Raushan Moldasheva   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source