Results 161 to 170 of about 7,064,987 (293)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Optimization of nanopore sequencing for surveillance of antimicrobial resistance in low-resource settings. [PDF]

Front Public Health
Thornval NR, Lacy-Roberts N, Rebelo AR, Nilsson P, Mourão J, Gibson C, Hasman H, Hendriksen RS.   +7 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Computing the effects of excitatory-inhibitory balance on neuronal input-output properties. [PDF]

PLoS Comput Biol
Reyes AD.
europepmc   +1 more source

Distributed scheduling in input queued switches [PDF]

, 2007
Bianco, Andrea, Giaccone, Paolo, Leonardi, Emilio, Schiattarella, E., Scicchitano, A.   +4 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Making PLUMED Fly: A Tutorial on Optimizing Performance. [PDF]

J Phys Chem B
Rapetti D, Bonomi M, Camilloni C, Bussi G, Tribello GA.   +4 more
europepmc   +1 more source

Electronic Greetings for President Wilson [PDF]

, 2005
Community input
core   +1 more source

Asynchronous vs synchronous input-queued switches [PDF]

, 2010
Bianco, Andrea, Cuda, Davide, Giaccone, Paolo, Neri, Fabio   +3 more
core   +1 more source