Results 211 to 220 of about 218,068 (267)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Huddles for unprofessional behaviours in the healthcare setting that may require immediate investigation, inquiry or intervention. [PDF]

BMJ Lead
Baldwin CA, Catron TF, Hickson GB, Aberson S, Anderson RM, Bledsoe S, Brodman M, Cauwels J, Dmochowski R, Hemmen T, Hoenerman B, Johnson R, Kapoor S, Lee D, Lillie D, Mekeel K, Meranze S, Moate D, Perry W, Robbins SL, Savides TJ, Shah BJ, Thillman K, Uthe C, Tomaszewski C, Wade B, Webb L, Cooper WO.   +27 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

"You're not just there to do a job": a qualitative examination of Canadian long-term care worker strengths. [PDF]

BMC Health Serv Res
Goonetilleke D, Boettcher N, Celis S, Lashewicz B.   +3 more
europepmc   +1 more source

A Leveson Inquiry (The Leveson Inquiry)

In Medias Res, 2014
openaire   +1 more source

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Inquiry on Inquiry

Journal of Management Inquiry, 2006
The subject matter of this article is the discussions that occurred during the process of conceptualizing and writing a paper on the philosophy of organizational science. These discussions reflect some of the tensions inherent in academic writing and publishing, as well as personal and intellectual tensions, which can make the writing process ...
C. Murat Alpaslan, Marin Babb, Sandy Edward Green, Ian I. Mitroff   +3 more
openaire   +1 more source

Inquiry in psychology

Integrative Psychological and Behavioral Science, 2022
When they discuss the Danish academic situation, Szulevicz, Lund and Lund (2021) address three questions about the academic training of psychology researchers: (a) why do Danish master's students in psychology more frequently choose the qualitative method for their research?; (b) what are psychology students working on?; and (c) what are they ...
Maria Virginia Machado Dazzani, Waldomiro José Silva-Filho   +1 more
openaire   +2 more sources

A Shared Inquiry into Shared Inquiry

The Public Historian, 2006
Shared inquiry is a key component of reflective public history practice. All good historical practice is reflective, but public history requires a special commitment to collaborate, to respond, to share both inquiry and authority. Because trained practitioners and lay people often seek different pasts for different purposes, public historians may find ...
Katharine T. Corbett, Howard S. (Dick) Miller   +1 more
openaire   +1 more source

Inquiry into Inquiry

Improving College and University Teaching, 1957
(1957). Inquiry into Inquiry. Improving College and University Teaching: Vol. 5, No. 4, pp. 93-99.
openaire   +1 more source

Appreciative Inquiry

The Journal of Continuing Education in Nursing, 2008
Appreciative inquiry, which emphasizes using affirmative questions, can help create a positive environment. J Contin Educ Nurs 2008;39(3):104.
Diane M. Billings, Karren Kowalski
openaire   +2 more sources