Results 231 to 240 of about 2,160,968 (306)

2018 Inquiry Journal: Abstracts [PDF]

, 2018
Casellini, Brigid C
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coaching and Individualized Learning in Competency-Based Medical Education: Framework Development and Research Priorities. [PDF]

AEM Educ Train
Mand SK, Wolff M, Zamignani N, Williams SR, Santen SA, Scott KR, Garrett A, Brown C, Kim JG, Dorfsman ML, Caretta-Weyer H, Branzetti J.   +11 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Combating converging crises: The role of universities in global health, climate, and equity. [PDF]

J Clim Chang Health
Ratevosian J, Aikins AD, Bhutta Z, Bravo M, Dugas L, Fanzo J, Fornace K, Guinto R, Hernández D, Just A, Kapwata T, Koh LP, Korfmacher K, Luby S, Monteiro W, Nelson L, O'Meara W, Pan W, Tighe R, Beyrer C, Steelman T.   +20 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The DSM validation method and its decision points: value judgments, metaphysical presuppositions, and validators. [PDF]

Hist Philos Life Sci
Rodríguez Puente A.
europepmc   +1 more source

Psychological support for people affected by scandals caused by serious and sustained failings of statutory services and government: lessons from the infected blood scandal and Infected Blood Inquiry. [PDF]

BJPsych Open
Carlisle J, Cyhlarova E, Warren E, Knapp M, Nolte E.   +4 more
europepmc   +1 more source

Using an AI-powered Mobile Application Chatbot to Address Maternal Depression Indicators and Inquiries in the Perinatal and Postpartum Periods: A Multimethod Analysis. [PDF]

Inquiry
Peters CJ, Aldana Lainez V, Clark K, Jasczynski M, Nguyen QC, Norell EM.   +5 more
europepmc   +1 more source

Correction: Leave or stay? A narrative inquiry of tensions in novice English teachers' professional identity construction at China's private universities. [PDF]

Front Psychol
Zhang X.
europepmc   +1 more source