Results 61 to 70 of about 10,885 (206)

Ocular manifestations of analgesia syndrom in children

Российский офтальмологический журнал, 2018
Congenital analgesia is characterized by insensitivity to pain. Children with this syndrome feel no physical pain when biting their tongues, lips, cheeks or fingers, which often results in significant bleeding.
L. S. Khamraeva, L. Yu. Bobokha
doaj   +1 more source

Manufacturing Nostalgia in the Digital Age: A Foreverism Perspective

Psychology &Marketing, EarlyView.
ABSTRACT Many scholars argue that we are experiencing the era of “retro”—nostalgia‐driven marketing and consumption phenomena reinforced by digital technologies. However, existing research lacks a critical analysis of nostalgia in contemporary markets and of how digital content, tools, and environments transform retro consumption experiences and alter ...
Dinara Davlembayeva, Davit Marikyan, Jonatan Sodergren, Savvas Papagiannidis, Simos Chari   +4 more
wiley   +1 more source

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source

Syntaxin1A overexpression and pain insensitivity in individuals with 7q11.23 duplication syndrome

JCI Insight
Genetic modifications leading to pain insensitivity phenotypes, while rare, provide invaluable insights into the molecular biology of pain and reveal targets for analgesic drugs.
Michael J. Iadarola, Matthew R. Sapio, Amelia J. Loydpierson, Carolyn B. Mervis, Jill C. Fehrenbacher, Michael R. Vasko, Dragan Maric, Daniel P. Eisenberg, Tiffany A. Nash, J. Shane Kippenhan, Madeline H. Garvey, Andrew J. Mannes, Michael D. Gregory, Karen F. Berman   +13 more
doaj   +1 more source

Congenital Insensitivity to Pain without Anhidrosis: Orodental Problems and Management

Case Reports in Dentistry, 2015
This paper reports the case of a 4-year-old male patient who was brought by parents requesting for replacement of multiple missing anterior teeth. The patient suffered from congenital insensitivity to pain without anhidrosis and presented with full blown
N. Abdullah, Kausar Sadia Fakhruddin, A. R. Samsudin   +2 more
doaj   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

A scalable workflow for sensitive detection and genomic profiling of tumour cells in lymph nodes from FFPE tissue

The Journal of Pathology, EarlyView.
Abstract Accurate detection of lymph node (LN) metastases is critical for prognosis and surgical decision‐making in head and neck squamous cell carcinoma (HNSCC) and other epithelial cancers. Standard histopathology examines only a small fraction of LN tissue, limiting sensitivity for micrometastases and isolated tumour cells.
Tristan Bergmann, Marianne Hölbling, Monica Sudarsanam, Christiane Driemel, Maximilian E Daniels, Joanna Swierz, Sandra Jaschinski, Maximilian Seidl, Norbert R Kübler, Wolfram T Knoefel, Rui PL Neves, Karl C Sproll, Nikolas H Stoecklein   +12 more
wiley   +1 more source

Deciphering the Structural and Functional Effects of the R1150W Non-Synonymous Variant in SCN9A Linked to Altered Pain Perception

NeuroSci
The SCN9A gene, a critical regulator of pain perception, encodes the voltage-gated sodium channel Nav1.7, a key mediator of pain signal transmission.
Faisal A. Al-Allaf, Zainularifeen Abduljaleel, Mohammad Athar   +2 more
doaj   +1 more source

Sentipensar [Feel‐Thinking] Cultivates Collective Scientific Sensemaking and Worldbuilding Within and Beyond Ecological Despair

Science Education, EarlyView.
ABSTRACT Educating youth about environmental and climate justice is crucial in realizing a sustainable and flourishing future. Yet this can be challenging given the intense eco‐emotions youth experience and express while learning about these consequential realities and their implications.
Kelsie Fowler
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source