Results 51 to 60 of about 721,748 (274)

Immunomodulation stimulates the innervation of engineered tooth organ [PDF]

open access: yes, 2014
The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from
Bécavin, Thibault   +5 more
core   +5 more sources

Influence of Cutting Parameters and Tool Geometry on Topography of Hard Turned Surfaces

open access: yesMachines, 2023
Three-dimensional topography measurement is a focus area of precision machining because it provides detailed information on the functional behavior of contacting surfaces.
Viktor Molnar
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

open access: yes, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela   +7 more
core   +1 more source

Investigation of wear of ultra high molecular weight polyethylene in a soft tissue behaviour knee joint prosthesis wear test simulator

open access: yesJournal of Materials Research and Technology, 2019
Knee joint prostheses are commonly employed for therapy in over-use disorder, and as a result of traffic accident and sports injuries. However, errors that can occur due to their use need to be defined.
Erkan Bahçe, Ender Emir
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Data modelling for emergency response [PDF]

open access: yes, 2010
Emergency response is one of the most demanding phases in disaster management. The fire brigade, paramedics, police and municipality are the organisations involved in the first response to the incident.
Dilo, Arta, Zlatanova, Sidi
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Firebird Database Backup by Serialized Database Table Dump [PDF]

open access: yes, 2007
This paper presents a simple data dump and load utility for Firebird databases which mimics mysqldump in MySQL. This utility, fb_dump and fb_load, for dumping and loading respectively, retrieves each database table using kinterbasdb and serializes the ...
Ling, Maurice HT
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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