Results 71 to 80 of about 726,918 (272)

An Access Control Model for Protecting Provenance Graphs [PDF]

, 2015
Postprin
Chen, Liang, Edwards, Peter, Nelson, John D, Norman, Timothy J   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Evaluation of the Efficiency of Heat Exchanger Channels with Different Flow Turbulence Methods Using the Entropy Generation Minimization Criterion

Energies
This paper presents the results of an optimization analysis of two types of thermal fluid channels. The selected geometries were evaluated according to the criterion of the Entropy Generation Minimization method as suggested by Adrian Bejan, with ...
Piotr Bogusław Jasiński, Grzegorz Górecki, Zbigniew Cebulski   +2 more
doaj   +1 more source

Joining of Thermoplastic Composites with Metals Using Resistance Element Welding

Applied Sciences, 2020
Joining is a key enabler for a successful application of thermoplastic composites (TPC) in future multi-material systems. To use joining technologies, such as resistance welding for composite-metal joints, auxiliary joining elements (weld inserts) can be
Juliane Troschitz, Julian Vorderbrüggen, Robert Kupfer, Maik Gude, Gerson Meschut   +4 more
doaj   +1 more source

Congregational bonding social capital and psychological type : an empirical enquiry among Australian churchgoers [PDF]

, 2012
This study explores the variation in levels of bonding social capital experienced by individual churchgoers, drawing on data generated by the Australian National Church Life Survey, and employing a five-item measure of church-related bonding social ...
Baker C, Bellamy J, Craig CL, Delis-Bulhoes V, DeVellis RF, Francis LJ, Francis LJ, Francis LJ, Francis LJ, Gerhardt R, Jung CG, Kaldor P, Kaldor P, Kaldor P, Kaldor P, Kaldor P, Kaldor P, Keirsey D, Leslie J. Francis, Mandy Robbins, Myers IB, Myers IB, Putnam RD, Rehak MC, Ross CFJ, Ross CFJ, Ruth Powell, Woolcock M   +27 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An Approximate Maximum Common Subgraph Algorithm for Large Digital Circuits [PDF]

, 2010
This paper presents an approximate Maximum Common Subgraph (MCS) algorithm, specifically for directed, cyclic graphs representing digital circuits. \ud Because of the application domain, the graphs have nice properties: they are very sparse; have many ...
Hölzenspies, Philip K.F., Kuper, Jan, Rutgers, Jochem H., Smit, Gerard J.M., Wolkotte, Pascal T.   +4 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The effect of land use on benthic communities in Hawkes Bay streams of differing geology : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Ecology at Massey University [PDF]

, 1999
Benthic macroinvertebrate and periphyton communities of streams draining four different land use types within four distinct geological types were sampled between December 1996 and January 1997.
Gibson, Jason Ross
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source