Results 71 to 80 of about 721,748 (274)

Placing three-dimensional isoparametric elements into NASTRAN [PDF]

, 1973
Linear (8 node), parabolic (20 node), cubic (32 node) and mixed (some edges linear, some parabolic and some cubic) have been inserted into NASTRAN, level 15.1. First the dummy element feature was used to check out the stiffness matrix generation routines
Filstrup, A. W., Newman, M. B.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Energy simulations of a transparent-insulated office facade retrofit in London, UK [PDF]

, 2012
Purpose – Transparent insulation materials (TIMs) have been developed for application to building facades to reduce heating energy demands of a building.
Eames, Philip, Perera, Srinath, Wong, Ing Liang   +2 more
core   +1 more source

Curcumin In Situ Gelling Polymeric Insert with Enhanced Ocular Performance

Pharmaceutics, 2020
The search for an ocular drug delivery system that could provide long-acting effects without a detriment to the anatomy and physiology of the eye remains a challenge.
Hamdy Abdelkader, David Wertheim, Barbara Pierscionek, Raid G. Alany   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Evaluation of the Efficiency of Heat Exchanger Channels with Different Flow Turbulence Methods Using the Entropy Generation Minimization Criterion

Energies
This paper presents the results of an optimization analysis of two types of thermal fluid channels. The selected geometries were evaluated according to the criterion of the Entropy Generation Minimization method as suggested by Adrian Bejan, with ...
Piotr Bogusław Jasiński, Grzegorz Górecki, Zbigniew Cebulski   +2 more
doaj   +1 more source

Joining of Thermoplastic Composites with Metals Using Resistance Element Welding

Applied Sciences, 2020
Joining is a key enabler for a successful application of thermoplastic composites (TPC) in future multi-material systems. To use joining technologies, such as resistance welding for composite-metal joints, auxiliary joining elements (weld inserts) can be
Juliane Troschitz, Julian Vorderbrüggen, Robert Kupfer, Maik Gude, Gerson Meschut   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Evaluation of Dynamic Cell Processes and Behavior Using Video Bioinformatics Tools [PDF]

, 2015
Just as body language can reveal a person’s state of well-being, dynamic changes in cell behavior and morphology can be used to monitor processes in cultured cells.
A Valavanidis, BE Lehnert, C Ballestrem, C Carlson, C Gieseke, CC Wong, DA Drechsel, DR Albrecht, E Hinchcliffe, F Li, G DiCarlantonio, G Schatten, GG Martin, K Riveles, K Riveles, K Riveles, K Riveles, KL Tsai, M Knoll, M Knoll, M Williams, P Talbot, P Talbot, P Talbot, RZ Behar, RZ Behar, S Inoué, S Lin, S Lin, S Lin, T Haraguchi, T Ichikawa, V Adler, V Bahl, VJ Thannickal, Y Wang   +35 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source