Results 131 to 140 of about 401,827 (385)

Economic costs associated with insomnia in adults with subthreshold depression or major depressive disorder

open access: yesBJPsych Open
Background Previous studies have found substantial costs to be associated with depression and insomnia (as separate entities). Aims To estimate healthcare service use and costs associated with insomnia in Australian adults experiencing subthreshold ...
Phuong Hong Le   +4 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams   +7 more
wiley   +1 more source

Insomnia and limb pain in hemodialysis patients: What is the share of restless leg syndrome?

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2012
Insomnia and limb pain are common problems in dialysis patients. In addition, restless leg syndrome (RLS) as a specific cause of insomnia and limb pain has been reported in many studies. The purpose of this study was to estimate incidence of insomnia and
Majid Malaki   +3 more
doaj   +1 more source

El insomnio [PDF]

open access: yes, 2007
Insomnia is a common pathology in the general population. It is estimated that 10 to 15 percent of the adult population has chronic insomnia and 25 to 35 percent have suffered occasional or transient insomnia due to stressful situations.
Castro-Manglano, P. (Pilar) de   +1 more
core   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi   +11 more
wiley   +1 more source

Impact of migraine on the clinical presentation of insomnia: a population-based study

open access: yesThe Journal of Headache and Pain, 2018
Background Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms.
Jiyoung Kim   +5 more
doaj   +1 more source

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan   +7 more
wiley   +1 more source

Insomnia as an independent predictor of suicide attempts: a nationwide population-based retrospective cohort study

open access: yesBMC Psychiatry, 2018
Background Numerous studies have verified that insomnia is associated with suicidal ideation, suicide attempts, and death by suicide. Limited population-based cohort studies have been conducted to examine the association.
Han-Ting Lin   +6 more
doaj   +1 more source

PENGARUH TERAPI MUSIK RELIGI TERHADAP KEJADIAN INSOMNIA PADA MENOPAUSE DI POSYANDU LANSIA DESA SURUH SUKODONO SIDOARJO [PDF]

open access: yes, 2017
Permasalahan yang sering dialami oleh wanita menopause salah satunya insomnia dikarenakan proses alamiah dalam kehidupan.Data di Desa Suruh Sukodono Sidoarjo banyak sekali wanita menopause yang mengalami insomnia.
MAISAROH, SITI
core   +1 more source

Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis.

open access: yesSleep Medicine Reviews, 2022
E. Hertenstein   +14 more
semanticscholar   +1 more source

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