Results 61 to 70 of about 171,701 (311)

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Prevalence of OSA Risk and Bruxism in Children With Autism Spectrum Disorders

Autism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) often present with sleep disorders, including obstructive sleep apnea (OSA), a condition characterized by upper airway obstruction during sleep. Bruxism has been recently described as being associated with OSA.
Anna Alessandri‐Bonetti, Federica Guglielmi, Andrea Faustini, Linda Sangalli, Edoardo Staderini, Patrizia Gallenzi   +5 more
wiley   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Emotion dysregulation in insomnia disorder: the possible role of psychiatric comorbidity

Frontiers in Sleep
AimThe purpose of this study was to investigate the link between emotion dysregulation and insomnia disorder as well as the possible role of psychiatric comorbidity on the association.
Markus Jansson-Fröjmark, Samiul Hossain
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Economic costs associated with insomnia in adults with subthreshold depression or major depressive disorder

BJPsych Open
Background Previous studies have found substantial costs to be associated with depression and insomnia (as separate entities). Aims To estimate healthcare service use and costs associated with insomnia in Australian adults experiencing subthreshold ...
Phuong Hong Le, Long Khanh-Dao Le, Joahna Kevin Perez, Shantha M. W. Rajaratnam, Cathrine Mihalopoulos   +4 more
doaj   +1 more source

Mental Health Outcomes of Perceived Stress, Anxiety, Fear and Insomnia, and the Resilience among Frontline Nurses Caring for Critical COVID-19 Patients in Intensive Care Units

, 2022
Sinu Jose, Maneesha C Cyriac, Manju Dhandapani, Aseem Mehra, Navneet Sharma   +4 more
openalex   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Impact of migraine on the clinical presentation of insomnia: a population-based study

The Journal of Headache and Pain, 2018
Background Insomnia and migraine are closely related; insomnia aggravates migraine symptoms. This study was conducted to investigate the impact of migraine on the clinical presentation of insomnia symptoms.
Jiyoung Kim, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu   +5 more
doaj   +1 more source

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, EarlyView.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source