Results 31 to 40 of about 950,100 (309)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Savaş Yıllarında Menteşe Livası'ndaki İbtidaî Mekteplerinin Genel Durumu 1916-1917

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018
Tanzimat dönemi, Osmanlı Devleti için büyük değişimi ifade etmektedir ve bu değişimden etkilenen alanlardan birisi de eğitimdir. 1869 yılında yürülüğe giren Maârif-i Umûmiye Nizamnâmesi ile ilk defa bu alanda etraflı bir düzenleme yapılmış ve devlet ...
Muttalip Şimşek
doaj  

Wide-Area Vehicle-Drone Cooperative Sensing: Opportunities and Approaches

open access: yesIEEE Access, 2019
The last decade has witnessed unmanned aerial vehicles (UAVs) emerging as a powerful platform for various industrial and civilian applications. However, refrained by limited battery capacities, the hovering time of UAVs is still limited, impeding them ...
Kai Peng   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Evaluation of testing procedures for real-scale sewage pipes

open access: yesWater Science and Technology, 2021
Tests to determine the tightness of wastewater pipes can in some cases produce results that are worthy of discussion. Therefore, testing procedures for real-scale sewage pipes used for house connections were evaluated and data were statistically analysed.
S. Ulutaş, M. Wichern, B. Bosseler
doaj   +1 more source

Meat Inspection [PDF]

open access: yesThe Veterinary Journal (1900), 1900
n ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Official quality controls and the fight against fraud in the olive oil sector in Catalonia. Results 2011–2014

open access: yesGrasas y Aceites, 2016
This article highlights the key aspects of the official control procedures concerning quality and in the fight against food fraud in the oil sector implemented in Catalonia by the Ministry for Agriculture, Livestock, Fisheries and Food of the Government ...
G. Cugat, M. R. Biel
doaj   +1 more source

New trends in visual inspection of buildings and structures: Study for the use of drones

open access: yesOpen Engineering, 2021
Visual inspection is a very simple, non-destructive technique and usual in diagnosing buildings and structures’ conditions. It also plays an important role in the rapid assessment of constructive problems as well as in the definition of an appropriate ...
Falorca Jorge Furtado   +2 more
doaj   +1 more source

Kinematic Model Pruning: A Design Optimization Technique for Simultaneous Optimization of Topology and Geometry

open access: yesRobotics, 2022
This paper presents a method of optimizing the design of robotic manipulators using a novel kinematic model pruning technique. The optimization departs from an predefined candidate linkage consisting of a initial topology and geometry.
Hannes Gamper   +4 more
doaj   +1 more source

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