Results 31 to 40 of about 812,863 (268)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A New Direct and Inexpensive Method and the Associated Device for the Inspection of Spur Gears

Machines, 2023
This paper proposes a new rapid and straightforward method along with a related device for finding the three basic parameters of an actual external involute spur gear. The number of teeth is easily counted, but the other two parameters—the module and the
Stelian Alaci, Florina-Carmen Ciornei, Ionut-Cristian Romanu, Ioan Doroftei, Carmen Bujoreanu, Ioan Tamașag   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Assessing Critical Adaptations in Automated Adaptive Software Systems by Stage Decomposition

IEEE Access
In environments involving a variety of connected devices and systems, there is an ever-increasing demand for automated adaptation. To ensure that all threats are identified and manageable in such environments, quality assurance activities including ...
Shuji Morisaki, Michiyo Wakimoto, Norimitsu Kasai   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Computer Vision-Based Path Planning with Indoor Low-Cost Autonomous Drones: An Educational Surrogate Project for Autonomous Wind Farm Navigation

Drones
The application of computer vision in conjunction with GPS is essential for autonomous wind turbine inspection, particularly when the drone navigates through a wind farm to detect the turbine of interest. Although drones for such inspections use GPS, our
Angel A. Rodriguez, Mohammad Shekaramiz, Mohammad A. S. Masoum   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

“The ultimate goal of education is to give the Orthodox Russian Church a truly Christian pastor, a worthy patriot son to the Motherland, and an honest and cultured person to society”. Educational process in Leningrad theological schools in the 1940 s [PDF]

Вестник Свято-Филаретовского института
Based on archival materials, the article examines the educational process in Leningrad theological academy and seminary in the 1940 s. The first inspector after the revival of theological schools in Leningrad was Archpriest Alexander Osipov.
Karpuk D. A.
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Savaş Yıllarında Menteşe Livası'ndaki İbtidaî Mekteplerinin Genel Durumu 1916-1917

Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018
Tanzimat dönemi, Osmanlı Devleti için büyük değişimi ifade etmektedir ve bu değişimden etkilenen alanlardan birisi de eğitimdir. 1869 yılında yürülüğe giren Maârif-i Umûmiye Nizamnâmesi ile ilk defa bu alanda etraflı bir düzenleme yapılmış ve devlet ...
Muttalip Şimşek
doaj