Results 91 to 100 of about 3,165,406 (373)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Applied SciencesMetallic ore deposits are generally formed through magmatic intrusions, followed by metamorphism. The geological structures in such regions are often complex, with mechanical parameters exhibiting significant variability.
Guangzhi Chai +5 more
doaj +1 more source
Screw instability of the magnetic field connecting a rotating black hole with its surrounding disk
, 2003 Screw instability of the magnetic field connecting a rotating black hole (BH) with its surrounding disk is discussed based on the model of the coexistence of the Blandford-Znajek (BZ) process and the magnetic coupling (MC) process (CEBZMC).
Blandford R. D. +7 more
core +1 more source
Theoretical EconomicsWe study a model in which two players with opposing interests try to alter a status quo through instability‐generating actions. We show that instability can be used to secure longer‐term durable changes, even if it is costly to generate and does not generate short‐term gains.
Barilla, César, Gonçalves, Duarte
openaire +3 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Applied SciencesThe duration of water immersion significantly affects the mechanical response of rock materials. This study investigated the weakly cemented sandstone from the Wulagen Open-pit Mine to examine how varying immersion times affected the mineral composition,
Honglei Liu +5 more
doaj +1 more source
Experimental and numerical evaluation on debonding of fully grouted rockbolt under pull-out loading
International Journal of Coal Science & Technology, 2022 The axial loading in rockbolts changes due to stress redistribution and rheology in the country rock mass. Such a change may lead to debonding at rockbolt to grout interface or rupture of the rockbolt.
Shuisheng Yu, Wancheng Zhu, Leilei Niu
doaj +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX
Nature CommunicationsThe growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness +18 more
doaj +1 more source