Results 81 to 90 of about 1,090,662 (312)
Applied SciencesConventional unconditional random field (URF) models were shown to neglect in-situ monitoring data and thus misrepresent real slope stability. To address this, a conditional random field (CRF) generator was proposed, in which Fast Fourier Transform (FFT)
Xin Dong +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Jet noise from instability mode interactions [PDF]
, 2008 A nonlinear interaction model is used to study sources of sound in jets. The model uses quadratic interactions of instability modes, which are obtained by solving the linear parabolized stability equations.
Salgado, Adriana M. +5 more
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The Rayleigh–Taylor instability of two-dimensional high-density vortices [PDF]
, 2005 We investigate the stability of variable-density two-dimensional isolated vortices in the frame of incompressible mixing under negligible gravity. The focus on a single vortex flow stands as a first step towards vortex interactions and turbulent mixing ...
Fontane, Jérôme +2 more
core +1 more source
Study on Rockburst Nucleation Process of Deep-Buried Tunnels Based on Microseismic Monitoring
Shock and Vibration, 2015 The objective of this study was to investigate the rockburst nucleation process and provide a theoretical basis for its prediction. A microseismic monitoring system was established in deep tunnels at Jinping II Hydropower Station.
Qun Yu +4 more
doaj +1 more source
The instability of studies of instability [PDF]
Journal of Evolutionary Biology, 1997 M. C. Whitlock, K. Fowler
openaire +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
The Growth Effects of Institutional Instability [PDF]
Both institutional quality and institutional stability have been argued to stimulate economic growth. But to improve institutional quality, a country must endure a period of institutional change, which implies at least a little and possibly a lot of ...
Berggren, Niclas +2 more
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