Results 91 to 100 of about 2,614,548 (357)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX
Nature CommunicationsThe growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness +18 more
doaj +1 more source
Influence of the mean flow on zonal flow generation
, 2008 Excitation of zonal flow by the modulational instability in the presence of mean shear flow is considered. It is shown that the small amplitude mean flow favours the modulational instability, increasing the growth rate, whereas sufficiently strong mean ...
Lashkin, V. M.
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Numerical Simulation on Damage and Failure Mechanism of Rock under Combined Multiple Strain Rates
Shock and Vibration, 2018 During underground hard-rock mining, the drilling and blasting method currently remains the most economical excavation method, and the rock may experience a multistrain-rate spectrum under quasi-static, dynamic, and rheological loading conditions and ...
Wancheng Zhu +4 more
doaj +1 more source
Growth, Volatility & Political Instability: Non Linear Time Series Evidence for Argentina 1896-2000 [PDF]
, 2007 What is the relationship between economic growth and its volatility? Does political instability affect growth directly or indirectly, through volatility?
Campos, Nauro F., Karanasos, Menelaos
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Gravitational instability caused by the weight of heat
, 2019 Thermal energy points toward a disordered, completely uniform state acting counter to gravity's tendency to generate order and structure through gravitational collapse.
Roupas, Zacharias
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source