Results 61 to 70 of about 808,650 (268)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Numerical Simulation on Damage and Failure Mechanism of Rock under Combined Multiple Strain Rates

Shock and Vibration, 2018
During underground hard-rock mining, the drilling and blasting method currently remains the most economical excavation method, and the rock may experience a multistrain-rate spectrum under quasi-static, dynamic, and rheological loading conditions and ...
Wancheng Zhu, Jiong Wei, Leilei Niu, Shuai Li, Shaohua Li   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A novel transfer learning-enhanced BiLSTM-DCNN architecture for mine microseismic signal identification with small data set

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
The underground mining environment generates highly heterogeneous microseismic (MS) signals, whose accurate identification is crucial for source localization and failure mechanism analysis. Limited data in the early monitoring stages restrict recognition
Yong Zhao, Shihui Jiao, Tianhong Yang, Yao Wang, Haiyan Xu, Zhengdong Liu   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Numerical Shear Tests on the Scale Effect of Rock Joints under CNL and CND Conditions

Advances in Civil Engineering, 2020
The scale effect of rock joint shear behavior is an important subject in the field of rock mechanics. There is yet a lack of consensus regarding whether the shear strength of rock joints increases, decreases, or remains unchanged as the joint size ...
Xige Liu, Wancheng Zhu, Lankun Li
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Conditional Random Field Approach Combining FFT Filtering and Co-Kriging for Reliability Assessment of Slopes

Applied Sciences
Conventional unconditional random field (URF) models were shown to neglect in-situ monitoring data and thus misrepresent real slope stability. To address this, a conditional random field (CRF) generator was proposed, in which Fast Fourier Transform (FFT)
Xin Dong, Tianhong Yang, Yuan Gao, Wenxue Deng, Yang Liu, Peng Niu, Shihui Jiao, Yong Zhao   +7 more
doaj   +1 more source

Author Correction: ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2018
This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source