Results 61 to 70 of about 1,282,741 (306)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Open questions in the treatment of anterior shoulder instability

, 2010
Risk factors for recurrence of shoulder instability after Bankart ...
P.S. Randelli
core   +1 more source

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

Nature Communications
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova   +18 more
doaj   +1 more source

Research on the Dynamic Response Patterns of Layered Slopes Considering Non-Homogeneity Under Blast-Induced Vibration Effects

Applied Sciences
To investigate the dynamic wave propagation characteristics and dynamic response of heterogeneous layered slopes under a blasting vibration, a modeling method considering the slope’s layered dip angle and heterogeneity was proposed. Different dip jointed
Yong Zhao, Yanjie Liu, Shihui Jiao, Tianhong Yang, Wenxue Deng, Shuhong Wang   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology
Over several decades, therapeutic advances have transformed oncology, yet for many tumour types, survival improvements have been incremental, with substantial treatment‐related morbidity. A decisive pivot in oncology, from treating established malignancy
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
doaj   +1 more source

Analysis of Surrounding Rock Stability Based on Refined Geological and Mechanical Parameter Modeling—A Case Study

Applied Sciences
Metallic ore deposits are generally formed through magmatic intrusions, followed by metamorphism. The geological structures in such regions are often complex, with mechanical parameters exhibiting significant variability.
Guangzhi Chai, Yong Zhao, Tianhong Yang, Qianbai Zhao, Shihui Jiao, Jinduo Li   +5 more
doaj   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Endogenous Political Instability [PDF]

In this paper, we construct a simple dynamic two-party electoral competition model in which the degree of political instability is endogenously determined.
Ryo Arawatari, Kazuo Mino
core