Results 51 to 60 of about 750,440 (268)

Integrated Physical Microstructure and Mechanical Performance Analysis of the Failure Mechanism of Weakly Cemented Sandstone Under Long-Term Water Immersion

Applied Sciences
The duration of water immersion significantly affects the mechanical response of rock materials. This study investigated the weakly cemented sandstone from the Wulagen Open-pit Mine to examine how varying immersion times affected the mineral composition,
Honglei Liu, Shixian Zhang, Wenxue Deng, Jinduo Li, Tianhong Yang, Jianhua Zhou   +5 more
doaj   +1 more source

A prediction model for surface deformation caused by underground mining based on spatio-temporal associations

Geomatics, Natural Hazards & Risk, 2022
Accurate predictions of the surface deformation caused by underground mining are crucial for the safe development of underground resources. Although surface deformation has been predicted by artificial intelligence (AI) methods, most AI models are ...
Min Ren, Guanwen Cheng, Wancheng Zhu, Wen Nie, Kai Guan, Tianhong Yang   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Research on the Dynamic Response Patterns of Layered Slopes Considering Non-Homogeneity Under Blast-Induced Vibration Effects

Applied Sciences
To investigate the dynamic wave propagation characteristics and dynamic response of heterogeneous layered slopes under a blasting vibration, a modeling method considering the slope’s layered dip angle and heterogeneity was proposed. Different dip jointed
Yong Zhao, Yanjie Liu, Shihui Jiao, Tianhong Yang, Wenxue Deng, Shuhong Wang   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX

Nature Communications
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type annotation ...
Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova   +18 more
doaj   +1 more source

Analysis of Surrounding Rock Stability Based on Refined Geological and Mechanical Parameter Modeling—A Case Study

Applied Sciences
Metallic ore deposits are generally formed through magmatic intrusions, followed by metamorphism. The geological structures in such regions are often complex, with mechanical parameters exhibiting significant variability.
Guangzhi Chai, Yong Zhao, Tianhong Yang, Qianbai Zhao, Shihui Jiao, Jinduo Li   +5 more
doaj   +1 more source

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability

Nature Communications, 2017
MDC1 is a key component of the DNA damage response and interacts with several factors such as γ-H2AX. Here the authors show that MDC1 interacts with ID3, facilitating MDC1 recruitment to sites of damage and repair of breaks.
Jung-Hee Lee, Seon-Joo Park, Gurusamy Hariharasudhan, Min-Ji Kim, Sung Mi Jung, Seo-Yeon Jeong, In-Youb Chang, Cheolhee Kim, Eunae Kim, Jihyeon Yu, Sangsu Bae, Ho Jin You   +11 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology
Over several decades, therapeutic advances have transformed oncology, yet for many tumour types, survival improvements have been incremental, with substantial treatment‐related morbidity. A decisive pivot in oncology, from treating established malignancy
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
doaj   +1 more source