Results 31 to 40 of about 1,282,741 (306)

The curse of instability

open access: yesComplexity, 2015
High-dimensional computational challenges are frequently explained via the curse of dimensionality, i.e., increasing the number of dimensions leads to exponentially growing computational complexity. In this commentary, we argue that thinking on a different level helps to understand, why we face the curse of dimensionality.
openaire   +3 more sources

Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation

open access: yesExperimental and Molecular Medicine
Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear ...
Jeeho Kim   +4 more
doaj   +1 more source

A hybrid recognition model of microseismic signals for underground mining based on CNN and LSTM networks

open access: yesGeomatics, Natural Hazards & Risk, 2021
Microseismic (MS) monitoring technology has been widely used to monitor ground pressure disasters. However, the underground mining environment is complex and contains many types of noise sources.
Yong Zhao   +4 more
doaj   +1 more source

Establishment of landslide early-warning indicator using the combination of numerical simulations and case matching method in wushan open-pit mine

open access: yesFrontiers in Earth Science, 2022
Landslides seriously threaten the safety of human life and property. In order to predict the on-set of potential landslides, this paper first characterizes the physical and mechanical parameters of rock mass on the basis of core rock quality designation ...
Penghai Zhang   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Görtler instability [PDF]

open access: yesThe Physics of Fluids, 1981
Görtler instability for boundary-layer flows over generally curved walls is considered. The full-linearized disturbance equations are obtained in an orthogonal curvilinear coordinate system. A perturbation procedure to account for second-order effects is used to determine the effects of the displacement thickness and the variation of the streamline ...
Ragab, Saad A., Nayfeh, Ali H.
openaire   +2 more sources

The growth impact of political regimes and instability: impirical evidences from Western Europe [PDF]

open access: yes, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awared by Brunel University.The main objective of this thesis is to investigate the reciprocal direct relationship between political regimes, political instability and economic growth ...
Dimitraki, Ourania
core   +6 more sources

Cell Cycle Analysis of Candida albicans by Flow Cytometry

open access: yesBio-Protocol, 2023
The cell cycle is a vital process of cell division that is required to sustain life. Since faithful cell division is critical for the proper growth and development of an organism, the study of the cell cycle becomes a fundamental research objective ...
Shraddheya Patel   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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