Results 21 to 30 of about 877,036 (297)

ATR is required to complete meiotic recombination in mice

Nature Communications, 2018
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and ...
Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés, Ignasi Roig   +11 more
doaj   +1 more source

Research progress and prospect of intelligent prediction and disaster risk assessment of open-pit mining surface deformation

矿业科学学报
Research on the prediction and disaster risk assessment of surface deformation in open-pit mines serves to improve the accuracy of disaster warning and make safety control decisions.
LI Hui, ZHU Wancheng, XU Xiaodong, SONG Qingwei, HAN Xiaofei, GENG Huikai   +5 more
doaj   +1 more source

Establishment of landslide early-warning indicator using the combination of numerical simulations and case matching method in wushan open-pit mine

Frontiers in Earth Science, 2022
Landslides seriously threaten the safety of human life and property. In order to predict the on-set of potential landslides, this paper first characterizes the physical and mechanical parameters of rock mass on the basis of core rock quality designation ...
Penghai Zhang, Wenxue Deng, Feiyue Liu, He Wang, Xin Dong, Peng Niu   +5 more
doaj   +1 more source

Carbon emission accounting and decarbonization pathways for high-altitude and cold-region open-pit metal mines: A life cycle assessment approach

工程科学学报
Amid the depletion of conventional resources, the development of high-altitude cold-region mines has emerged as a strategic avenue to secure resource supplies and drive industrial upgrades.
Guiqi LI, Kai GUAN, Wancheng ZHU, Wenxue DENG, Yang LIU, Tianhong YANG, Runze ZHU   +6 more
doaj   +1 more source

A hybrid recognition model of microseismic signals for underground mining based on CNN and LSTM networks

Geomatics, Natural Hazards & Risk, 2021
Microseismic (MS) monitoring technology has been widely used to monitor ground pressure disasters. However, the underground mining environment is complex and contains many types of noise sources.
Yong Zhao, Haiyan Xu, Tianhong Yang, Shuhong Wang, Dongdong Sun   +4 more
doaj   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation

Experimental and Molecular Medicine
Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear ...
Jeeho Kim, Young Jin Jeon, In-Youb Chang, Jung-Hee Lee, Ho Jin You   +4 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Cell Cycle Analysis of Candida albicans by Flow Cytometry

Bio-Protocol, 2023
The cell cycle is a vital process of cell division that is required to sustain life. Since faithful cell division is critical for the proper growth and development of an organism, the study of the cell cycle becomes a fundamental research objective ...
Shraddheya Patel, Satya Sahu, Narottam Acahrya   +2 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source