Results 231 to 240 of about 341,388 (268)
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Mechanisms of telomeric instability
Cytogenetic and Genome Research, 2008Telomeres are the nucleoprotein structures that cap the ends of linear chromosomes. The length of telomeric DNA is an important determinant of function; with short telomeres triggering either replicative senescence or, in the absence of a functional DNA damage response, telomere fusion.
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Chromosomal instability—mechanisms and consequences
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015Chromosomal instability is defined as a state of numerical and/or structural chromosomal anomalies in cells. Numerous studies have documented the incidence of chromosomal instability, which acutely or chronically may lead to accelerated ageing (tissue-wide or even organismal), cancer or other genetic disorders.
Shriram Venkatesan +2 more
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2008
Abstract This chapter is focused on mechanical instabilities, which give rise to microstructure pattern formation and eventual failure of stressed solids. Plastic instabilities are described in detail because of their importance in understanding the mechanical behaviour of materials, and because of the strong link between mechanical ...
Nasr M. Ghoniem, Daniel D. Walgraef
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Abstract This chapter is focused on mechanical instabilities, which give rise to microstructure pattern formation and eventual failure of stressed solids. Plastic instabilities are described in detail because of their importance in understanding the mechanical behaviour of materials, and because of the strong link between mechanical ...
Nasr M. Ghoniem, Daniel D. Walgraef
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Fragmentation in the mechanical instability region
Physical Review C, 1986By means of a cascade model calculation, it is shown that medium mass fragment production in proton-induced reactions very likely proceeds via the breakup of the residual nuclear system rather than coalescence. The reaction trajectory of the excited nuclear system is found to enter the mechanical instability region with S/Aapprox.0.4, well below the ...
, Boal, , Goodman
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Mechanical instabilities of homogeneous crystals
Physical Review B, 1995Elastic stability criteria are derived for homogeneous lattices under arbitrary but uniform external load. These conditions depend explicitly on the applied stress and reduce, in the limit of vanishing load, to the criteria due to Born, involving only the elastic constants of the crystal.
, Wang, , Li, , Yip, , Phillpot, , Wolf
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Mechanisms of Genomic Instability in Breast Cancer
Trends in Molecular Medicine, 2019Breast cancer is the most common cancer among women globally. Genomic instability (GI) refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is a hallmark of cancer. Genomic integrity is closely guarded by several mechanisms, including DNA damage checkpoints, the DNA repair machinery, and the mitotic checkpoint ...
Duijf, Pascal H.G. +5 more
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Molecular Mechanisms of TRS Instability
2002To date several neurodegenerative disorders including myotonic dystrophy, Huntington's disease, Kennedy's disease, fragile X syndrome, spinocerebellar ataxias or Friedreich's ataxia have been linked to the expanding trinucleotide sequences. Although phenotypic features vary among these debilitating diseases, the structural abnormalities of the triplet ...
Pawel, Parniewski, Pawel, Staczek
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On the flowers‐ruderman instability mechanism
Astronomische Nachrichten, 1981AbstractFlowers und Ruderman untersuchten im Zusammenhang mit Neutronensternen das Stabilitätsverhalten von Konfigurationen, bei denen die magnetischen Feldlinien aus einem elektrisch leitenden Medium, in dem hydrostatisches Gleichgewicht herrscht, in umgebendes Vakuum austreten und wieder zurückgehen.
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Growth instabilities in mechanical breakdown
Physical Review E, 1994A linear stability analysis of a circular crack growing in an elastic medium in two dimensions is presented. Two boundary conditions at the outer boundary are considered, namely, a constant strain and a constant pressure. Size effects are included by assuming a finite distance between the inner and the outer boundaries.
, Louis, , Guinea
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Mechanisms of combustion instability
Symposium (International) on Combustion, 1965This paper presents results of a study aimed at understanding mechanisms involved in triggering, amplification, and suppression of acoustic waves, due to presence of flames. Experiments performed demonstrate that strong interactions between acoustic and flame oscillations can exist through flow oscillations, and that these interactions are due to ...
Tau-Yi Toong +3 more
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