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Molecular mechanisms of plaque instability
Current Opinion in Lipidology, 2007Coronary artery thrombosis superimposed on a disrupted atherosclerotic plaque initiates abrupt arterial occlusion and is the proximate event responsible for 60-80% cases of acute coronary syndromes. This article provides a concise update on the evolving concepts in the pathophysiology of plaque rupture and thrombosis.Over the past several years, the ...
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Mechanisms leading to chromosomal instability
Seminars in Cancer Biology, 2005Chromosomal instability is a common feature of cancer cells. Several cellular mechanisms lead to numerical and structural chromosomal instability in cancer cells, including defects in chromosomal segregation, cellular checkpoints that guard against reproduction of abnormal cells, telomere stability, and the DNA damage response.
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Mechanical Instabilities of Gels
Annual Review of Condensed Matter Physics, 2012Although the study of gels undoubtedly takes its roots within the field of physicochemistry, the interest in gels has flourished and they have progressively become an important object in the study of the mechanics of polymeric materials and volumetric growth, raising some fascinating problems, some of them remaining unsolved.
Julien Dervaux, Martine Ben Amar
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On the Inventory Cycle and the Instability of the Competitive Mechanism
Econometrica, 1989Summary: This paper presents a model of the business cycle with perfect foresight where the mere presence of inventories is responsible for the appearance of the cycle. The basic assumption of the model is that the price system does not adjust instantaneously to its competitive value.
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Morphogenesis and mechanical instability of a prestressed tissue
Biochemistry and Cell Biology, 1995We consider the issue of whether purely mechanical properties of biological systems can, in principle, play a significant role in morphogenesis. As a simple example, we model a spherically arranged epithelium that is symmetrically prestressed under the action of cytoskeletal elements.
J, Totafurno, M, Bjerknes
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Mechanisms of germ line genome instability
Seminars in Cell & Developmental Biology, 2016During meiosis, numerous DNA double-strand breaks (DSBs) are formed as part of the normal developmental program. This seemingly destructive behavior is necessary for successful meiosis, since repair of the DSBs through homologous recombination (HR) helps to produce physical links between the homologous chromosomes essential for correct chromosome ...
Seoyoung, Kim +3 more
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Instability Mechanisms and Countermeasures
1998The objective of this chapter is to provide a classification of the basic loss of stability mechanisms relevant to voltage phenomena and to point out appropriate countermeasures. In the previous chapter we have seen that a gradual parameter variation may result in a loss of stability through a saddle-node bifurcation. However, in many voltage incidents
Thierry Cutsem, Costas Vournas
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Instabilities of Triplet Repeats: Factors and Mechanisms
1998Repetitive DNA sequences are dispersed throughout natural genomes, both within and outside of known coding sequences (Charlesworth et al. 1994; Tautz and Schlotterer 1994). The varied distribution of particular repetitive sequences between different species suggests that they fulfill specific cellular requirements, but direct evidence for what these ...
R D, Wells, A, Bacolla, R P, Bowater
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