Results 71 to 80 of about 3,284,414 (262)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Tax Revenue Instability in Sub-Saharan Africa: Consequences and Remedies [PDF]

This paper focuses on the sources and consequences of the instability of tax revenue in Sub-Saharan African countries. We take advantage of a unique and extraordinarily rich dataset on the composition of tax revenues for a large number of countries ...
Hélène Ehrhart, Christian Ebeke
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Study of disaster-prone geological structures and instability modes of typical goaf landslides in mountainous areas of southwest China

Dizhi lixue xuebao
Objective  Landslides occur frequently in the goaf areas of mountainous areas in Southwest China. This study aims to explore the commonalities and differences among such landslides to support the development of scientific disaster prevention and ...
ZHANG Haoxiang, ZHU Sainan, YAO Leihua, GAO Feng, ZHANG Limei, YANG Long, TAN Weijia, DAI Xusheng, GAO Yu   +8 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Design of a crab-like bistable mechanism for nearly equal switching forces in forward and backward directions

, 2018
A compliant bistable mechanism with a crab-like structure for nearly equal switching forces in the forward and backward directions is developed. It consists of four crab-leg-like beams and a shuttle mass.
Dung-An Wang, 王東安, Ngoc Dang Khoa Tran   +2 more
core   +1 more source

Numerical Simulation of Aerodynamic Instability Mechanisms in the Diffuser of a Multistage Centrifugal Compressor

Fluids
The main reason for limiting the working flow range of the compressor is the unstable flow phenomenon of the compressor working at a small flow rate, including stall, surge, and rotational instability.
Zhuhai Zhong, Xiaodan Zhang, Kunlun Bai, Meng Wang, Xiaodong Lu   +4 more
doaj   +1 more source

Present Situation and Prospect of Research on Prevention and Control Technologies of Coal Mine Goaf Instability Disaster

Meikuang Anquan, 2020
Aiming at the instability disaster of coal mine goaf, based on the disaster type and hazard analysis, the present situation and progress of the research on the prevention and control technology of the mine goaf instability hazards in China are ...
WANG Donghao, LI Wen, ZHANG Bin
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source