Results 61 to 70 of about 341,388 (268)

Mechanisms of oncogene-induced genomic instability [PDF]

Biophysical Chemistry, 2017
Activating mutations in oncogenes promote uncontrolled proliferation and malignant transformation. Approximately 30% of human cancers carry mutations in the RAS oncogene. Paradoxically, expression of mutant constitutively active Ras protein in primary human cells results in a premature proliferation arrest known as oncogene-induced senescence (OIS ...
Simona, Graziano, Susana, Gonzalo
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Study on the influence mechanism of interface dip angle on damage and failure of coal-rock combinations under confining pressure

Meikuang Anquan
To investigate the failure and instability mechanism of coal-rock combinations with different interface dip angles, a series of conventional triaxial compression simulation tests under a confining pressure of 4 MPa were conducted on coal-rock ...
Weiguang WANG, Gaofei LIU, Jiazhi SUN, Feng DU   +3 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Study of disaster-prone geological structures and instability modes of typical goaf landslides in mountainous areas of southwest China

Dizhi lixue xuebao
Objective  Landslides occur frequently in the goaf areas of mountainous areas in Southwest China. This study aims to explore the commonalities and differences among such landslides to support the development of scientific disaster prevention and ...
ZHANG Haoxiang, ZHU Sainan, YAO Leihua, GAO Feng, ZHANG Limei, YANG Long, TAN Weijia, DAI Xusheng, GAO Yu   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Present Situation and Prospect of Research on Prevention and Control Technologies of Coal Mine Goaf Instability Disaster

Meikuang Anquan, 2020
Aiming at the instability disaster of coal mine goaf, based on the disaster type and hazard analysis, the present situation and progress of the research on the prevention and control technology of the mine goaf instability hazards in China are ...
WANG Donghao, LI Wen, ZHANG Bin
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Transient Voltage Stability Analysis of the Dual-Source DC Power System

Energies
This paper analyzes the transient voltage stability of the dual-source DC power system. The system’s equivalent model is first established. Subsequently, the effect mechanisms of line parameters and voltage-source rectifiers’ current control inner loops ...
Yi Lei, Yang Li, Feng Zhao, Yelun Peng, Zhen Mei, Zhikang Shuai   +5 more
doaj   +1 more source