Results 41 to 50 of about 406 (203)

Dynamic Lifetime Prediction of Fishing Nets Based on the Model of Wave Return Period and Residual Strength

Journal of Marine Science and Engineering, 2022
The classical cumulative damage method based on the S-N curve or crack growth model is unrealistic for predicting the lifetime of fishing nets under actual service conditions.
Hong Wang, Hua Yuan, Yao Zhao, Jun Yan
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Installation Disturbance of Helical Anchor in Dense Sand and the Effect on Uplift Capacity Based on Discrete Element Method

Journal of Marine Science and Engineering
Helical anchors have been extensively employed as foundation systems for carrying tension loads due to their installation efficiency and large uplift capacity.
Rong Chen, Hu Liu, Dongxue Hao, Zhaoguo Liu, Chi Yuan   +4 more
doaj   +1 more source

Industrial Design of Yarn Speed Monitoring System in Positive Feed Circular Knitting Machine

Tekstilec, 2023
As constant yarn feeding tension is essential in the formation of uniform stitches, the lack of a monitoring system in a circular weft knitting machine capable of measuring the uniformity of the yarn feeding speed in different driven belts and comparing
Mohammad Ehsan Momeni Heravi
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effectiveness and Safety of Prolonged Needle Decompression Procedures in Tension Pneumothorax Patients with COVID-19

Indonesian Journal of Anesthesiology and Reanimation (IJAR), 2022
Introduction: Coronavirus disease-19 (COVID-19) has become a pandemic that is still ongoing today. This is a new challenge for health workers in handling emergency cases. Several COVID-19 patients arrived at the hospital with severe respiratory problems.
Mirza Koeshardiandi, Zulfikar Loka Wicaksana, Bambang Pujo Semedi, Yoppie Prim Avidar   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Surdat: Database of physical properties of lead-free solders [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy, 2007
The results of investigations, carried out since 1998, of surface tension by the maximum bubble pressure method, and of density by the dilatometric method for pure metals, binary and multicomponent systems have been used to create an electronic database ...
Moser Z., Gasior W., Debski A., Pstrus J.   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source