Results 51 to 60 of about 1,903,000 (307)
Core competencies, product families and sustained business success [PDF]
, 1992 Includes bibliographical references (p. 22-24).Supported by the Center for Innovation Management Studies at Lehigh University, the Leaders for Manufacturing Program at MIT, and the International Center for Research on the Management of Technology at the ...
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in Plant ScienceMaize (Zea mays L.) production is severely affected by diseases and insect pests, leading to significant yield losses when timely diagnosis and management interventions are not implemented.
Niranjan Singh +7 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Information for choice: what people need, prefer and use - Executive summary for the National Institute for Health Research Service Delivery and Organisation programme [PDF]
, 2011 First paragraph: Choice is at the heart of all Government health policies but is meaningless without information. Information is pivotal to people's experience of choice and self-management.
Hunt, Kate +6 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Institutional Work in Management and Organizational Research
, 2019 Abstract Although the study of institutional work developed relatively recently it has inspired a significant body of research investigating how agents purposefully engage with their institutional context in order to create, modify, or disrupting institutions.
Thomas B. Lawrence, Nelson Phillips
openaire +1 more source
, 1989 Project number related to IDRC support could not be determinedAbstracts in English and FrenchThe table of contents for this item can be shared with the requester.
International Crops Research Institute for the Semi-Arid Tropics +1 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source