Results 71 to 80 of about 1,903,000 (307)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A simple guide to water quality management in fish ponds
, 1990 (37 page document)Formerly: Kainji Lake Research Institute ISSN: 0331 ...
Ovie, S.I., Adeniji, H.A.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Institute for Operations Research and the Management Sciences [PDF]
INFORMS Journal on Computing, 2003 +5 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Institute for Operations Research and the Management Sciences [PDF]
INFORMS Journal on Computing, 2004 +5 more sources
Frontiers in Marine Science, 2019 Coastal waters provide a wide range of ecosystem services (ES), but are under intensive human use, face fast degradation and are subject to increasing pressures and changes in near future. As consequence, European Union (EU) water policies try to protect,
Gerald Schernewski +7 more
doaj +1 more source
Instructional research management in an educational institution
Общество: социология, психология, педагогика, 2018 The paper deals with the development and testing of the institutional research management scheme in an educational institution. This scheme is based on the axiological, systemic, and activity approaches. It is founded on the principles of differentiation, activity, and effectiveness.
openaire +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source