Results 121 to 130 of about 1,010,719 (266)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Locked-Window EQ-5D-5L (Index and VAS) Benchmarking in Sarcoma Care: Rule-Based Traffic-Light Classification Across Two Institutions. [PDF]

Diseases
Gloor I, Meier B, Rexhai J, Heesen P, Schelling G, Vogel B, Studer G, Fuchs B, On Behalf Of The Swiss Sarcoma Network.   +8 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

CICU Workforce Surveys: Interpret With Caution. [PDF]

JACC Adv
Lotfi A.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Clinical Utility of [¹⁸F]-Fluciclovine PET/MRI for Differentiating True Progression from Treatment-Related Changes in Patients with Glioblastoma. [PDF]

AJNR Am J Neuroradiol
Ivanidze J, Vu KV, Fu R, Brandmaier A, Szidonya L, Choudhary G, Starkey J, Wang TJ, Sisti M, McKhann LG, Puri S, Konner M, Roytman M, Lin E, Kuhn A, Osborne JR, Stieg PE, Beal K, Ramakrishna RR, Singh G, Lignelli-Dipple A, Doubrovin M, Vo AH, Welch M, Iwamoto F, Haggiagi A, Donovan L, Ordonez MD, Gill B, Liechty B, Pisapia DJ, Walker J, Magge RS, Wood M, Corzo VM, Sanusi OR, Raslan A, Dogan A, Bowden S, Nehmeh SA, Nickerson J, Mallak N, Ruiz A, Ambady P, Nabavizadeh A, Barajas RF.   +45 more
europepmc   +1 more source

Les institutions et les exigences paradoxales de la modernité

Trivium, 2021
Jean-François Kervégan, Christian Schmidt, Benno Zabel   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Reality of BPH Surgery Price and Reimbursement Across Top U.S. Hospitals. [PDF]

Urol Pract
Murray G, Edmonds V, Borah B, Kelleher D, Wymer KM.   +4 more
europepmc   +1 more source