Results 111 to 120 of about 6,330,812 (290)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Institutional Credit through Cooperatives in Maharashtra: A Region-wise Analysis [PDF]
In the era of financial sector reforms, sustainability, viability and operational efficiency of rural financial institutions (RFIs) are the major issues that need to be taken cognizance of in ensuring effective rural credit delivery system.
Shah, Deepak
core +4 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Historical and Comparative Institutional Analysis: Evidences from Deforestation [PDF]
This paper investigates if past institutional, economic, political, social, and cultural features (i.e legal origins on law and regulations and colonial legacies) interact in shaping the current institutional performances on deforestation in 116 ...
Sébastien MARCHAND
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
An Institutional Analysis of European Systems for Impact Assessment [PDF]
Agricultural and Food Policy, Environmental Economics and Policy, Farm Management, Land Economics/Use,
Adamowicz, Mieczyslaw +4 more
core +1 more source
INDUSTRIAL TRANSFORMATION IN THE AFTERMATH OF THE CRISIS: An Empirical Analysis of Industrial Policies in France, Germany, Spain and the United Kingdom. CES Open Forum Series 2018-2019, 2019 [PDF]
, 2019 This paper gauges the forces and structures that shape economic transformation through an analysis of industrial polices in four European economies since the 2008 crisis: France, Germany, Spain and the United Kingdom.
Calvo, Angela Garcia, Coulter, Steve
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Institutional Tax Clienteles and Payout Policy [PDF]
This paper employs heterogeneity in institutional shareholder tax characteristics to identify the relationship between firm payout policy and tax incentives.
Li Jin, Mihir A. Desai
core