Results 131 to 140 of about 23,831,433 (300)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Towards a quasi-Lamarckian theory of institutional change. [PDF]
The paper emphasises two flaws in mainstream economics: the failure to understand human behaviour and the belittling of transaction costs. By stressing the role of knowledge, institutions and path dependence, new institutional economics has provided a ...
Enrico Colombatto
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
International Trade and Institutional Change [PDF]
This paper analyzes the impact of international trade on the quality of institutions, such as contract enforcement, property rights, or investor protection. It presents a model in which institutional differences play two roles: they create rents for some
Andrei A. Levchenko
core
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Institutional change, rural services, and agricultural performance in Kyrgyzstan: [PDF]
The institutional change in rural Kyrgyzstan during the transition period included farm reorganization, land reform, building markets, and community institutions.
Omuraliev, Nurbek, Akramov, Kamiljon T.
core
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
INSTITUTIONAL Change as Cultural Change. An Illustration by Chinese Postsocialist Transformation [PDF]
Culture of a society reflects its social values. So, through Chinese experience, we want to show that institutional change is not only an economic or a political process but fundamentally a cultural one.
EL KAROUNI, Ilyess
core
Modern Dönem Osmanlı Maliyesine Analitik Bir Bakış
İstanbul İktisat Dergisi, 2018 Bu makalenin amacı, 18. yüzyılın ikinci yarısından başlayıp imparatorluğun son yıllarına kadar uzanan dönem kapsamında, Osmanlı idaresinin maliye politikalarını ve malî performansını analiz etmektir.
Yakup AKKUŞ
doaj
Exploring Institutional Change in the Context of a Statewide Developmental Education Reform in Florida. [PDF]
Community Coll J Res Pract, 2020 Mokher CG, Spencer H, Park TJ, Hu S.
europepmc +1 more source