Results 41 to 50 of about 17,325,720 (353)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Transition as Institutional Change [PDF]

, 2017
Tacking stock of the arguments built in previous chapters, we reframe the discussion so far to emphasise the role of institutions in the process of development.
Douarin, E, Mickiewicz, T
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Institutional Change, Sustainability and the Sea [PDF]

Sustainability, 2013
Currently, a substantial institutional change is under way for marine and coastal resources. Sustainability plays a major role therein. At the time of writing, roughly 2.3% of the marine and coastal territory has been declared a Marine Protected Area (MPA).
Achim Schlüter, Sarah Wise, Kathleen Schwerdtner Mánez, Gabriela De Morais, Marion Glaser   +4 more
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Rights in the Time of Populism: Land and Institutional Change Amid the Reemergence of Right-Wing Authoritarianism in Colombia

Land, 2019
In Colombia, right-wing leadership returned to power after winning the presidential elections in 2018 in a campaign in which they opposed the previous government, primarily because of the negotiations and peacemaking with the FARC-EP (Fuerzas Armadas ...
Sergio Coronado
doaj   +1 more source

Legitimacy and institutional change in international organisations: a cognitive approach

Review of International Studies, 2017
Why are some institutional designs perceived as more legitimate than others, and why is the same institutional design sometimes perceived as legitimacy-enhancing in one setting and not in another? In a world in which most international organisations (IOs)
Tobias Lenz, L. Viola
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Understanding institutions: different paradigms, different conclusions

RAUSP: Revista de Administração da Universidade de São Paulo
There is widespread agreement across the social sciences that institutions matter. Although there is widespread agreement that institutions shape the behavior of actors, there are disagreements over the extent to which they actually influence individuals
Daniel Friel
doaj   +1 more source

Los académicos como agentes de cambio institucional: el caso del Instituto Tecnológico de Sonora, 2003-2018

Región y Sociedad, 2020
El objetivo de este artículo es analizar los cambios institucionales en el Instituto Tecnológico de Sonora entre 2003 y 2018. La metodología empleada es el estudio de caso, además de fuentes primarias y entrevistas semiestructuradas; este método limita ...
Gabriel Galindo Padilla, Juan Poom Medina   +1 more
doaj   +1 more source