Results 81 to 90 of about 2,677,609 (309)

"Institutional Prerequisites of Financial Fragility within Minsky's Financial Instability Hypothesis: A Proposal in Terms of 'Institutional Fragility'" [PDF]

open access: yes
The relevancy of Minsky's Financial Instability Hypothesis (FIH) in the current (and still unfolding) crisis has been clearly acknowledged by both economists and regulators.
Christine Sinapi
core  

USE OF THE MATRIX MODEL PRINCIPLES FOR THE COMPLEX ASSESSMENT OF INSTITUTIONAL CHANGES EFFICIENCY

open access: yesМодернизация, инновация, развитие, 2016
Sustainable innovative development of the national enterprise environment is determined of effective institutes, institutional mechanisms of support of their development.
L. Leontieva, L. Orlova
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

INSTITUTIONAL EXTERNALITIES AS FACTORS OF INSTITUTIONAL CHANGES

open access: yesВестник Кемеровского государственного университета, 2013
The article states the authors' hypothesis about the ability of institutes and institutional formations to produce the external, side effects (externalities) which transforms them in one of the factors of the institutional changes.
T. A. Mikhailova
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Complementarity and institutional change: How useful a concept? [PDF]

open access: yes
The concept of institutional complementarity – i.e. the idea that the co-existence of two or more institutions enhances the functioning of each – is increasingly used to explain why institutions are resistant to change and why introducing new ...
Deeg, Richard
core  

Institutional Changes in Malaysia. New dimensions of challenges after the global financial crisis [PDF]

open access: yes, 2013
In this short article the author has tried to point out the hot spots for necessary institutional changes in Malaysia. As the term of financial crisis has been discussed among the leaders of ASEAN one can perceive indispensable changes on a social base ...
Raja, Paweł, Paweł Raja
core   +1 more source

Institutional Change

open access: yesSSRN Electronic Journal
Institutional change refers to the processes through which formal and informal rules governing social interaction are created, transformed, and replaced over time. Within the perspective of analytical sociology, institutional change is explained by identifying the micro-level mechanisms linking individual beliefs, preferences, and actions to macro ...
Huang Shaoan, Sun Shengmin
  +6 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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