Results 101 to 110 of about 24,289,840 (307)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Trade, Productivity and Institutional Quality: Issues and Empirics [PDF]

We estimate the relationship between productivity and trade for a panel of countries over the period 1980 to 2000 using instrumental-variables estimation of a productivity equation.
Martínez-Zarzoso, Inmaculada, Doyle, Eleanor   +1 more
core  

Impact of institutional quality on ecological footprint: New insights from G20 countries

, 2023
The complex relationship between institutional quality and ecological footprint (ECF) has been verified in prior literature; however, the subject is still inadequately explored and often disregarded to highlight areas where specific policy tensions exist.
Azimi, Mohammad Naim, Rahman, Mohammad Mafizur, Mohammad Mafizur Rahman, Mohammad Naim Azimi   +3 more
core   +1 more source

Institutional falls: quality not quantity [PDF]

Age and Ageing, 2004
McMurdo, Marion E. T., Harper, John R.
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Economic Development, Institutional Quality and Regional integration: Evidence from Africa Countries. [PDF]

The aim of this paper is to provide new empirical evidence about the determinants of per capita income in African countries, with particular attention to the affects of governance institutional quality and sub regional integration on income level. We use
Fabro, Gema, Enowbi Batuo, Michael
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interim Report of the Institutional Repository Policy Committee

, 2004
This is the Interim Report of the Institutional Repository Policy Committee dated 23 July 2004. Document includes the names of the Institutional Repository Policy Committee from 2003-2004.- Executive summary - Background and Perspective - Status of ...
Institutional Repository Policy Committee
core  

Post-Acquisition Operating Performance of Acquiring Firms following Cross-Border Mergers and Acquisitions

Economies
This study investigates the firms’ performance following cross-border mergers and acquisitions (M&As) from 2000 to 2022, employing the generalized method of moments (GMM) technique within the French context.
Aamir Khan, David Kalisz
doaj   +1 more source

Rule of Law, Institutional Quality and Information [PDF]

SSRN Electronic Journal, 2008
The focus of this paper is the analysis of the persistent lawlessness attitude observed in some transition and developing countries where an overall increase in the quality of institutions is recorded. The mechanism of information diffusion on institutional quality is explored using a model where the state confronts a continuum of agents prone to ...
openaire   +5 more sources