Results 121 to 130 of about 3,743,455 (314)

Quality Aspects In Institutional Translation: Introduction

open access: yes, 2017
Introduction to the ...
Svoboda, Tomáš   +2 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Does quality institutions promote environmental quality? [PDF]

open access: yesEnvironmental Science and Pollution Research, 2019
Ali, Hamisu Sadi   +6 more
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Institutions, policies and economic development. What are the causes of the shadow economy? [PDF]

open access: yes
What are the causes of the shadow economy? We provide new answers to this old question. The sharp distinction between theoretical priors on the institutional determinants of the shadow economy and the technique used for its measurement is the first novel
Luisanna Onnis, Patrizio Tirelli
core  

Institutions Quality and Growth [PDF]

open access: yes, 2009
We analyze the dynamic interaction between civil society organizations and Government in a representative developing economy. Government favors corruption and so fails to build efficient institutions. On its side, civil society exerts pressure on Government to constrain it to halt corruption.
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Quality Competition, Market Structure and Endogenous Growth [PDF]

open access: yes
This paper studies the role of quality competition in endogenous growth and institutional factors which can affect growth through affecting quality competition.
Jian Tong
core  

Elizabeth Carter, Assistant Professor of Political Science, COLA travels to France, Italy [PDF]

open access: yes, 2016
Prof. Carter conducted research, completed an article, met current contacts and made new institutional contacts for potential future collaborations for her project on the politics of quality food ...
Carter, Elizabeth
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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