Results 121 to 130 of about 16,823,829 (281)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Open access institutional repositories in India: insights from the OPENDOAR

Cybrarians Journal
Purpose: This paper aims to investigate the status of open access institutional repositories (OAIRs) in India as listed in the Directory of Open Access Repositories (OpenDOAR).
Deepak Singh
doaj   +1 more source

HELIN Institutional Repositories Committee minutes for 10/22/09

, 2009
Minutes of the Institutional Repositories Committee of the HELIN Consortium for October ...
HELIN Consortium. Institutional Repositories Committee
core  

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

The role of institutional repositories in addressing higher education challenges

, 2010
Over the last decade, Higher Education around the world is facing a number of challenges. Challenges such as adopting new technologies, improving the quality of learning and teaching, widening participation, student retention, curriculum design/alignment,
Tiropanis, Thanassis, Davis, Hugh, Sarker, Farhana   +2 more
core   +1 more source

Competencies for institutional repositories management: the case of the institutional repository of the University of Coimbra

, 2021
É num cenário de abertura crescente da ciência, mais amplo e complexo, que se impõem novas competências aos gestores de repositórios. Este estudo visa identificar os papéis e as competências necessárias à gestão e organização de um repositório institucional.
Ferreira, Beatriz Barrocas, Neves, Bruno, Miguéis, Ana Eva, Borges, Maria Manuel   +3 more
openaire   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Institutional Repository on a Shoestring

D-Lib Magazine, 2009
George Wrenn, Carolyn J. Mueller, Jeremy Shellhase   +2 more
openaire   +2 more sources

HELIN Institutional Repositories Committee minutes for 6/30/08

, 2008
Minutes of the Institutional Repositories Committee of the HELIN Consortium for June ...
HELIN Consortium. Institutional Repositories Committee
core