Results 311 to 320 of about 2,976,729 (360)

Integrative research and innovation strategy for rare diseases. Insights from the 5-year European joint programme on rare diseases, including analysis to inform recommendations for future actions. [PDF]

Health Res Policy Syst
Sánchez-González MDC, Sarmiento-Suárez R, Cellai LL, Moreau C, Bartoszewicz M, Fiedor P, Taruscio D, de Santis M, Posada de la Paz M, Julkowska D, Carta C, Bermejo-Sánchez E.   +11 more
europepmc   +1 more source

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Targeting differential energy substrate metabolism on a therapeutic ketogenic diet: a case report. [PDF]

Front Nutr
Russell KJ, Schwartz SEO.
europepmc   +1 more source

A Brief Primer on Institutional Repositories

Against the Grain, 2012
openaire   +4 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source

Food system determinants of seasonal malnutrition in children under 5 years in sub-Saharan Africa: a scoping review protocol. [PDF]

BMJ Open
Nasagre E, Dugle G, Bawontuo V.
europepmc   +1 more source

Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed precision dosing (MIPD) of tacrolimus in renal allograft recipients, evaluated in silico, demonstrated improved (time to and) probability of target concentration attainment and smaller deviations from target range. Using simulated tacrolimus concentration‐time profiles, a study of 200 patients was predicted to have sufficient power to ...
Dirk R.J. Kuypers, Pieter Annaert, Borefore Jallah, Maarten Naesens, Maxine Teuns, Annouschka Laenen, Ruben Faelens   +6 more
wiley   +1 more source

The Open Aurignacian Project: 3D scanning and the digital preservation of the Italian Paleolithic record. [PDF]

Sci Data
Falcucci A, Moroni A, Negrino F, Peresani M, Riel-Salvatore J.   +4 more
europepmc   +1 more source

Improving reproducibility of data analysis and code in medical research: 5 recommendations to get started. [PDF]

BMJ Open
Streiber AM, Hoepel SJW, Blok E, van Rooij FJA, Neitzel J, Labrecque J, Ikram MK, Bos D.   +7 more
europepmc   +1 more source

Research That Is Not Published Is Not Worth Doing. [PDF]

Indian J Psychol Med
Bipeta R.
europepmc   +1 more source