Results 151 to 160 of about 7,665 (266)

INVESTIGANDO INTERAÇÃO E MÚTUA DETERMINAÇÃO ENTRE CIÊNCIA E TECNOLOGIA [PDF]

The literature about the economics of science and technology (C&T) suggests not only that the technological innovation demands the expansion of the institutional borders between universities, research institutes, industrial firms and the financial system,
Catari Vilela Chaves, Sueli Moro
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

<i>CHEK2</i> germline variants in B-cell precursor acute lymphoblastic leukemia: findings in Mexican pediatric patients. [PDF]

Front Oncol
Martínez Anaya D, Fernández Hernández L, Valladares Coyotecatl M, Juárez Figueroa U, Dean M, Juárez Villegas L, Zapata Tarrés M, López Santiago N, Pérez-Vera P.   +8 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Taking High-Tech to the Field: Leukemia Diagnosis in Pediatric Mexican Patients from Vulnerable and Remote Regions. [PDF]

Diagnostics (Basel)
Ramírez-Ramírez D, Zamora-Herrera G, Romo-Rodríguez R, Cuéllar Mendoza M, Ayala-Contreras K, López Aguilar E, Zapata-Tarrés M, Pelayo R.   +7 more
europepmc   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Geographic and Socioeconomic Determinants of Treatment Abandonment in Pediatric Acute Leukemia: A Cohort Study in South-Central Mexico. [PDF]

Cancer Control
Núñez-Enriquez JC, Luna-Silva NC, Jacuinde-Trejo K, Flores-Lujano J, Medina-León D, Alarcón-Ruiz E, Garrido-Hernández MÁ, Cruz-Medina CS, Tinoco-Montejano D, Baños-Lara MDR, Campo-Martínez MLÁD, Duarte-Rodríguez DA, Allende-López A, Casique-Aguirre D, Elizarrarás-Rivas J, Olvera-Caraza D, Solís-Poblano JC, Terán-Cerqueda V, Ramírez-Ramírez D, Huerta-Moreno A, Aristil-Chery PM, Romo-Rodríguez R, Alvarez-Rodríguez E, Lien-Chang LEJ, Zamora-Herrera G, Hidalgo BG, Herrera-Olivares W, Ruíz-Arguelles GJ, Gallardo-Pérez MM, Chávez-Aguilar LA, Márquez-Toledo A, Cano-Cuapio LS, Ramos RH, Martínez-Martell MA, Ramirez-Ramirez AB, Brindis NR, Montiel-Jarquín AJ, Galván-Díaz CA, Velasco-Hidalgo L, Medina-Sanson A, Gutiérrez-Rivera ML, Cárdenas-Conejo A, Morales-Maravilla A, Victorio-García NP, Bekker-Méndez VC, Romero-Tlalolini MLÁ, Rodríguez-Espinosa JC, Mata-Rocha M, Olivares-Sosa AI, Rosas-Vargas H, Jiménez-Morales S, Martínez MEJ, Cárdenas-González M, Mejía-Aranguré JM, López-Aguilar E, Zapata-Tarrés M, Pelayo R.   +56 more
europepmc   +1 more source

Host and HBV Interactions and Their Potential Impact on Clinical Outcomes. [PDF]

Pathogens, 2023
Jose-Abrego A, Roman S, Laguna-Meraz S, Panduro A.   +3 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Serum OxLDL Levels Are Positively Associated with the Number of Ischemic Events and Damaged Blood Vessels in Patients with Coronary Artery Disease. [PDF]

Healthcare (Basel)
Perez-Robles M, Campos-Perez W, Godinez-Mora S, Lopez-Alvarez V, Ramos-Villalobos LE, Corona-Ruiz F, Armendariz-Borunda J, Martinez-Lopez E.   +7 more
europepmc   +1 more source