Results 151 to 160 of about 58,709,063 (261)

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources

Propofol infusion in critically ill patients is not associated with mitochondrial dysfunction or altered serum interleukin levels in the early sepsis response. [PDF]

Crit Care Sci
Nedel WL, Portela LV.
europepmc   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants. [PDF]

J Pathol Clin Res
Martínez Anaya D, Juárez-Velázquez MDR, Juárez Figueroa U, Dean M, Salas Labadía C, Valladares Coyotecatl M, Reyes León A, López Santiago N, Juárez Villegas L, Zapata Tarrés M, Pérez-Vera P.   +10 more
europepmc   +1 more source

<i>ABCC</i> Gene Variants and Their Effects on Non-Response and Relapse in Pediatric Patients with Central Nervous System Tumors: A Cohort Study. [PDF]

Curr Issues Mol Biol
Torres-Espíndola LM, Pérez-De Marcos JC, Castillejos-López MJ, Aquino-Gálvez A, Velasco-Hidalgo L, Cárdenas-Cardós R, De Uña-Flores A, Zapata-Tarrés M, Higuera-Iglesias A.   +8 more
europepmc   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

Animal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias, Antonio Jose Serrano‐Muñoz, Juan J. Segura‐Sampedro, Adriana M. Quintero‐Duarte, Joana M. Ramis, Marta Monjo   +5 more
wiley   +1 more source

<i>CHEK2</i> germline variants in B-cell precursor acute lymphoblastic leukemia: findings in Mexican pediatric patients. [PDF]

Front Oncol
Martínez Anaya D, Fernández Hernández L, Valladares Coyotecatl M, Juárez Figueroa U, Dean M, Juárez Villegas L, Zapata Tarrés M, López Santiago N, Pérez-Vera P.   +8 more
europepmc   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Functional Soy and Lupin Protein-Based Beverages Modulate Gut Microbiome and Attenuate Metabolic Dysregulation in Adolescent Boys with Overweight and Obesity. [PDF]

Nutrients
Guzmán TJ, Godínez-Méndez LA, Soto-Luna IC, Delgado-Rizo V, García-López PM, Romero-Velarde E, Vargas-Guerrero B, Hurtado-Díaz I, Salazar-Montes AM, Gurrola-Díaz CM.   +9 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source