Results 181 to 190 of about 6,791 (285)

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Serum OxLDL Levels Are Positively Associated with the Number of Ischemic Events and Damaged Blood Vessels in Patients with Coronary Artery Disease. [PDF]

Healthcare (Basel)
Perez-Robles M, Campos-Perez W, Godinez-Mora S, Lopez-Alvarez V, Ramos-Villalobos LE, Corona-Ruiz F, Armendariz-Borunda J, Martinez-Lopez E.   +7 more
europepmc   +1 more source

[Health insurance scheme: main contributor to inequalities in COVID-19 mortality in ColombiaTipo de cobertura de assistência à saúde: o principal fator contribuinte para as desigualdades em mortalidade por COVID-19 na Colômbia]. [PDF]

Rev Panam Salud Publica, 2022
Garzón-Orjuela N, Eslava-Schmalbach J, Gil F, Guarnizo-Herreño CC.   +3 more
europepmc   +1 more source

ASPECTOS TEÓRICOS E PRÁTICOS ASSOCIADOS À DECISÃO DE USO DE AGROTÓXICOS: UMA ABORDAGEM INTEGRADA ENTRE A AGRICULTURA, MEIO AMBIENTE E SAÚDE PÚBLICA. [PDF]

O objetivo desse artigo é discutir o que leva o agricultor a aplicar ou não os agrotóxicos, bem como ressaltar quais são os elementos que estão por traz dessa decisão.
Porto, Marcelo Firpo De Souza, Soares, Wagner Lopes   +1 more
core   +1 more source

Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
The study innovatively integrates single‐cell electric impedance identification and drug screening on a semiconductor chip, addressing tumor heterogeneity limitations. The system achieves label‐free cancer cell recognition while concurrently evaluating drug efficacy on cancer cells and toxicity on noncancerous cells.
Wenhao Hui, Ka‐Meng Lei, Yingying Liu, Xinru Huang, Yunlong Zhong, Xiaojun Chen, Mingji Wei, Jie Yan, Ren Shen, Pui‐In Mak, Rui P. Martins, Shuhong Yi, Ping Wang, Yanwei Jia   +13 more
wiley   +1 more source

Evaluation of the Analytical Performance of a Lateral Flow Assay for the Detection of Anti-Coccidioides Antibodies in Human Sera-Argentina. [PDF]

J Fungi (Basel)
Viale MN, Caceres DH, Mansilla PE, Lopez-Joffre MC, Vivot FG, Motter AN, Toranzo AI, Canteros CE.   +7 more
europepmc   +1 more source

Etiology, clinical characteristics, and risk factors associated with severe influenza-like illnesses in Mexican adults. [PDF]

IJID Reg, 2023
Guerra-de-Blas PDC, Ortega-Villa AM, Ortiz-Hernández AA, Ramírez-Venegas A, Moreno-Espinosa S, Llamosas-Gallardo B, Pérez-Patrigeon S, Hunsberger S, Magaña M, Valdez-Vázquez R, Freimanis L, Galán-Herrera JF, Guerrero-Almeida ML, Powers JH, Ruiz-Palacios GM, Beigel J, Galindo-Fraga A, Mexican Emerging Infectious Diseases Clinical Research Networka.   +17 more
europepmc   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

Influence of the leukoreduction moment of blood components on the clinical outcomes of transfused patients in the emergency department. [PDF]

Rev Bras Enferm
Silva NDMD, Herbst AC, André MR, Nogueira LS.   +3 more
europepmc   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source