Results 191 to 200 of about 627 (237)

PROSPECÇÃO TECNOLÓGICA DE PATENTES SOBRE CÂNCER DE MAMA NAS BASES DA WORLD INTELLECTUAL PROPERTY ORGANIZATION (WIPO), ESPACENET E INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL (INPI)

, 2017
Viviane Vaz, Áurea Machado de Aragão, Ilaria Bianchini, Antônio Martins de Oliveira, S. L. Russo, A. E. A. Paixão   +5 more
openalex   +2 more sources

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Clinical isolates of <i>Providencia rettgeri</i> and <i>Providencia Stuartii</i> evades neutrophil-mediated killing by subverting neutrophil-extracellular traps. [PDF]

Front Immunol
Castro JE, Birnberg-Weiss F, Toloza MJ, Bertinat YA, Fuentes F, Peyloubet A, Faccone D, Gómez SA, Landoni VI, Fernández GC.   +9 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Brigada de resíduos no serviço de hemoterapia do Instituto Nacional de Câncer (INCa): contribuições para a adequação do programa de gerenciamento de resíduos

, 2017
Simone Santos Peniche Rebouças
openalex   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Pirfenidone Reverts Global DNA Hypomethylation, Promoting DNMT1/UHRF/PCNA Coupling Complex in Experimental Hepatocarcinoma. [PDF]

Cells
Miranda-Roblero HO, Saavedra-Salazar LF, Galicia-Moreno M, Arceo-Orozco S, Caloca-Camarena F, Sandoval-Rodriguez A, García-Bañuelos J, Frias-Gonzalez C, Almeida-López M, Martínez-López E, Armendariz-Borunda J, Monroy-Ramirez HC.   +11 more
europepmc   +1 more source

Diagnosis and proposition of improvements in the management and supervision of service contracts applied to the Instituto National de Câncer José Alencar Gomes da Silva (INCA)

, 2016
Emilio Possidente Daher
openalex   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Characteristics and survival of adults with differentiated thyroid cancer in a Peruvian hospital. [PDF]

Rev Peru Med Exp Salud Publica
Morales-Concha L, Huamani-Linares I, Saihua-Palomino K, Luque Florez E, Chávez Echevarría A, Tupayachi Palomino RJ, Zea Nuñez CA, Mejia CR, Atamari-Anahui N.   +8 more
europepmc   +1 more source