Results 231 to 240 of about 6,791 (285)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp   +7 more
wiley   +1 more source

[Feminicide in Minas Gerais, Brazil: from characterization of events to spatiotemporal analysis]. [PDF]

open access: yesCad Saude Publica
Bahia CA   +7 more
europepmc   +1 more source

Molecular Profiling and Tumor Microenvironment in Sinonasal Mucosal Melanoma as Biomarkers for Enhanced Prognostic Stratification

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal mucosal melanoma (SNMM) is a rare and aggressive melanoma subtype with a notably poor prognosis. Despite molecular characterization advances, SNMM remains clinically challenging, highlighting the need for detailed molecular profiling.
Manuel Molina‐Garcia   +10 more
wiley   +1 more source

AI in Neurology: Everything, Everywhere, All at Once Part 1: Principles and Practice

open access: yesAnnals of Neurology, EarlyView.
Artificial intelligence (AI) is rapidly transforming healthcare, yet it often remains opaque to clinicians, scientists, and patients alike. This review, part 1 of a 3‐part series, provides neurologists and neuroscientists with a foundational understanding of AI's key concepts, terminology, and applications.
Matthew Rizzo, Jeffrey D. Dawson
wiley   +1 more source

Follicular Immune Landscaping Reveals a Distinct Profile of FOXP3hiCD4hi T Cells in Treated Compared to Untreated HIV. [PDF]

open access: yesVaccines (Basel)
Georgakis S   +13 more
europepmc   +1 more source

Conformational Change in a Four‐Tetrad DNA G‐Quadruplex upon Intercalation of a Small‐Molecule Ligand PyDH2

open access: yesAngewandte Chemie, EarlyView.
An exception or the rule? This work represents a second observation, and the first crystallographic evidence, of true intercalation of a small‐molecule ligand (here, bisquinolinium PyDH2) into an antiparallel G‐quadruplex (G4) DNA fold. Abstract G‐quadruplexes (G4s) are non‐canonical DNA structures implicated in a number of biological processes.
Kailey N. Martin   +7 more
wiley   +2 more sources

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