Results 41 to 50 of about 259 (195)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Organização da assistência oncológica terciária no Estado de São Paulo: Onco-Rede

Revista Brasileira de Cancerologia, 2023
Uma ação de caráter gerencial realizada no Estado de São Paulo foi a criação da Onco-Rede (Decreto Estadual nº 32.848, em 23 de janeiro de 1991), com o objetivo de servir de instrumento para identificar e constituir formalmente uma rede de hospitais que
Luiz Carlos Zeferino, Fernando Medina da Cunha, Paulo Emílio Pinto, Humberto Torloni, Aurélio Julião de Castro Monteiro, Francisco Ricardo Gualda Coelho, Cármino Antônio de Souza   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Construção e Validação de um Protocolo de Cuidados para Pacientes Críticos com Câncer em Delirium

Revista Brasileira de Cancerologia, 2021
Introdução: A frequência de delirium em unidades de terapia intensiva oncológica e elevada. Objetivo: Construir um protocolo de cuidados para pacientes com câncer em delirium, internados em uma unidade de terapia intensiva e investigar sua validade de ...
Bárbara Rocha Gouveia, Rafael Tavares Jomar, Débora Cristina Leitão dos Santos, Tânia Cristina de Oliveira Valente   +3 more
doaj   +1 more source

Dificuldades e deficiências na gestão organizacional do terceiro setor: um estudo de caso na Sociedade Grupo Voluntários da Esperança [PDF]

, 2007
TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Administração.O estudo desenvolvido teve como objetivo principal identificar as dificuldades e deficiências na Sociedade Grupo Voluntários da Esperança, uma ...
Furtado, Isabelle
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A História da Farmácia no INCA

Revista Brasileira de Cancerologia, 2002
De forma cronológica, o artigo retrata a História da Farmácia no INCA.
João Martins Dias Pires, Ilva Nolasco de Carvalho, Darcy da Silva Guimarães   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Portaria N° 6/77

Revista Brasileira de Cancerologia, 1977
Portaria n° 06 de 14 de janeiro de 1977.
Humberto Torloni
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source