Results 61 to 70 of about 259 (195)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Apresentação

Revista Brasileira de Cancerologia, 2023
Este número especial da Revista Brasileira de Cancerologia é editado em homenagem ao Dr. David A. Karnofsky.
Moacyr Santos Silva
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

O controle de gorduras trans em produtos de panificação comercializados nas lanchonetes do campus sede da Universidade Federal de Santa Catarina [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2015.O consumo alimentar da população tem sido influenciado por fatores como o menor tempo disponível para
Silva, Mariana Kilpp
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A História da Patologia no INCA

Revista Brasileira de Cancerologia, 2003
De forma cronológica, o artigo retrata a História da Patologia no INCA.
Lucilia Zardo, Francisco Fialho, Darcy da Silva Guimarães   +2 more
doaj   +1 more source

Análise do fomento à pesquisa em Saúde Sexual e Reprodutiva pelo Ministério da Saúde do Brasil [PDF]

, 2015
Monografia (graduação)—Universidade de Brasília, Faculdade de Ceilândia, Curso de Graduação em Saúde Coletiva, 2015.A produção de pesquisa em saúde tem reflexos positivos no setor quando bem direcionada e empregada pelas autoridades competentes, para ...
Soares, Letícia Carlos
core  

Latin american strategies for vaccination against human papillomavirus infection - a thematic review

, 2017
Objetivo: Conocer las estrategias para asumir la vacunación contra el virus del papiloma humano en América Latina a partir de una revisión temática internacional, para encontrar experiencias que contribuyan a mantener resultados satisfactorios en ...
Sabine Boogaard, Lida Janneth Salazar-Fajardo, Yolanda Marín, Benavides Delgado, Mónica Rocío, Marín, Yolanda, Lida Janneth Salazar Fajardo, Mónica Rocío Benavides Delgado, Sabine Boogaard, Mónica Rocío Benavides-Delgado, Yolanda Marín, Salazar Fajardo, Lida Janneth, Boogaard, Sabine   +11 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source